Varaico: Literature-Extracted Genetic Variants

Gene:UGT1A9
Variant:p.Y486D
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UGT1A9

NM_000463.3:p.Y486D

Associated Papers

Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients.

Xie XC et al.

Acta Pharmacologica Sinica, 2015

Association of the CYP2B6 c.516G>T polymorphism with high blood propofol concentrations in women from northern Greece.

Mastrogianni O et al.

Drug Metabolism and Pharmacokinetics, 2014

Genotype and allele frequencies of polymorphic UGT1A9 in the Polish population.

Zakerska O et al.

European Journal of Drug Metabolism and Pharmacokinetics, 2013

Compound heterozygote of a novel missense mutation (p.K402T) and a double missense mutation (p.[G71R;Y486D]) in type II Crigler-Najjar syndrome.

Maruo Y et al.

Journal of Pediatric Gastroenterology and Nutrition, 2011

Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment.

Ginsberg G et al.

Critical Reviews in Toxicology, 2010

Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9).

Takahashi H et al.

Basic & Clinical Pharmacology & Toxicology, 2008

Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.

Kurkela M et al.

Pharmacogenetics and Genomics, 2007

The interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specific, and may involve both monomers.

Kurkela M et al.

Biochemical Pharmacology, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."