Varaico: Literature-Extracted Genetic Variants

Gene:UGT2B7
Variant:p.D398N
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UGT2B7

NM_001074.4:p.D398N

Associated Papers

Insight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases.

Xue J et al.

Archives of Toxicology, 2025

Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters.

Iannaccone T et al.

Pharmaceuticals (basel, Switzerland), 2021

Pharmacogenomics in Papua New Guineans: unique profiles and implications for enhancing drug efficacy while improving drug safety.

Tucci JD et al.

Pharmacogenetics and Genomics, 2018

The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants.

Yang ZZ et al.

Acta Pharmacologica Sinica, 2017

Inter-isoform Hetero-dimerization of Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity.

Yuan LM et al.

Scientific Reports, 2016

Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity.

Yuan L et al.

Biochemical Pharmacology, 2015

Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment.

Li J et al.

Pharmacogenomics, 2012

Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen.

Wang H et al.

Biochemical Pharmacology, 2011

The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families.

Radominska-Pandya A et al.

Drug Metabolism Reviews, 2010

Update on tools for evaluation of uridine diphosphoglucuronosyltransferase polymorphisms.

Argikar UA et al.

Expert Opinion on Drug Metabolism & Toxicology, 2008

Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations.

Mehlotra RK et al.

European Journal of Clinical Pharmacology, 2007

Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.

Saeki M et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."