Varaico: Literature-Extracted Genetic Variants

Gene:UHRF1
Variant:p.G448D
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UHRF1

NM_001048201.3:p.G448D

Associated Papers

The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation.

Vaughan RM et al.

The Journal of Biological Chemistry, 2019

Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1.

Vaughan RM et al.

Proceedings of the National Academy of Sciences of the United States of America, 2018

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.

Avvakumov GV et al.

Nature, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."