Associated Papers
The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.
Karunakaran DKP et al.
Molecular Neurodegeneration, 2025
ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer's disease.
Chen G et al.
Neuron, 2025
Genetics of Alzheimer's disease: an East Asian perspective.
Miyashita A et al.
Journal of Human Genetics, 2023
Associations of risk genes with onset age and plasma biomarkers of Alzheimer's disease: a large case-control study in mainland China.
Jiao B et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2022
Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease.
Khani M et al.
Molecular Neurodegeneration, 2022
Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.
Chen G et al.
Science Advances, 2021
Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants.
Hoogmartens J et al.
Alzheimer's & Dementia (amsterdam, Netherlands), 2021
Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations.
Sprissler R et al.
Cancers, 2020
Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives.
Zhang DF et al.
Acs Chemical Neuroscience, 2019
Deconstructing and targeting the genomic architecture of human neurodegeneration.
De Jager PL et al.
Nature Neuroscience, 2018
The genetic landscape of Alzheimer disease.
Carmona S et al.
Handbook of Clinical Neurology, 2018
Genetics of Alzheimer's disease: From pathogenesis to clinical usage.
Shao W et al.
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 2017
UNC5C variants are associated with cerebral amyloid angiopathy.
Yang HS et al.
Neurology. Genetics, 2017
Molecular Genetics of Neurodegenerative Dementias.
Hinz FI et al.
Cold Spring Harbor Perspectives in Biology, 2017
Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.
White CC et al.
Plos Medicine, 2017
Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.
Freudenberg-Hua Y et al.
Human Molecular Genetics, 2016
An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling.
Hashimoto Y et al.
The Journal of Biological Chemistry, 2016
Genes associated with Alzheimer's disease: an overview and current status.
Giri M et al.
Clinical Interventions in Aging, 2016
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Wetzel-Smith MK et al.
Nature Medicine, 2014
Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China.
Jiao B et al.
Neurobiology of Aging, 2014
Identification of rare variants in Alzheimer's disease.
Lord J et al.
Frontiers in Genetics, 2014