Associated Papers
UPF1 regulates mRNA stability by sensing poorly translated coding sequences.
Musaev D et al.
Cell Reports, 2024
Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum.
Longman D et al.
Genes & Development, 2020
C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression.
Sun Y et al.
Nature Communications, 2020
Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1.
Kalathiya U et al.
International Journal of Molecular Sciences, 2019
The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.
Melero R et al.
Nature Communications, 2016
The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.
Hug N et al.
Cell Reports, 2014
A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.
Kurosaki T et al.
Genes & Development, 2014
Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.
Melero R et al.
Structure (london, England : 1993), 2014
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.
Ivanov PV et al.
The Embo Journal, 2008
Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay.
Behm-Ansmant I et al.
Genes & Development, 2006
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