Varaico: Literature-Extracted Genetic Variants

Gene:UPF1
Variant:p.G495R
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UPF1

NM_002911.4:p.G495R

Associated Papers

UPF1 regulates mRNA stability by sensing poorly translated coding sequences.

Musaev D et al.

Cell Reports, 2024

Elucidation of the Mechanism of Host NMD Suppression by HTLV-1 Rex: Dissection of Rex to Identify the NMD Inhibitory Domain.

Nakano K et al.

Viruses, 2022

Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation.

Park Y et al.

Nature Communications, 2020

Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1.

Kalathiya U et al.

International Journal of Molecular Sciences, 2019

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

Hug N et al.

Cell Reports, 2014

A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.

Kurosaki T et al.

Genes & Development, 2014

Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.

Isken O et al.

Cell, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."