Associated Papers
Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
Rennie ML et al.
Journal of Medicinal Chemistry, 2024
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Rennie ML et al.
Science Advances, 2022
Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination.
Lemonidis K et al.
The Febs Journal, 2022
USP1-trapping lesions as a source of DNA replication stress and genomic instability.
Coleman KE et al.
Nature Communications, 2022
Mutation of aspartic acid 199 in USP1 disrupts its deubiquitinating activity and impairs DNA repair.
Jang SW et al.
Febs Letters, 2021
Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Rennie ML et al.
Nature Structural & Molecular Biology, 2021
UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression.
Song H et al.
Nature Communications, 2020
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.
Arkinson C et al.
Life Science Alliance, 2018
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
Ha K et al.
Nature Communications, 2017
Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.
van Twest S et al.
Molecular Cell, 2017
Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity.
Olazabal-Herrero A et al.
The Febs Journal, 2016
The role of USP1 autocleavage in DNA interstrand crosslink repair.
Kim M et al.
Febs Letters, 2016
A novel role for the deubiquitinase USP1 in the control of centrosome duplication.
Jung JK et al.
Cell Cycle (georgetown, Tex.), 2016
Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Yin J et al.
Structure (london, England : 1993), 2015
FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.
Castella M et al.
Plos Genetics, 2015
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.
Olazabal-Herrero A et al.
Molecular Cancer, 2015
A noncanonical cysteine protease USP1 is activated through active site modulation by USP1-associated factor 1.
Villamil MA et al.
Biochemistry, 2012
USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.
Williams SA et al.
Cell, 2011
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.
Cotto-Rios XM et al.
The Journal of Cell Biology, 2011
Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
Kim JM et al.
Developmental Cell, 2009