Varaico: Literature-Extracted Genetic Variants

Gene:USP11
Variant:p.C275S
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USP11

NM_001371072.1:p.C275S

Associated Papers

ERK-mediated Cytoplasmic Retention of USP11 Contributes to Breast Cancer Cell Proliferation by Stabilizing Cytoplasmic p21.

Li L et al.

International Journal of Biological Sciences, 2022

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses.

Deng T et al.

Proceedings of the National Academy of Sciences of the United States of America, 2018

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.

Stockum A et al.

Plos One, 2018

29293652 (PubMed )
Supplement: pone.0190513.s001.pdf

USP11 regulates p53 stability by deubiquitinating p53.

Ke JY et al.

Journal of Zhejiang University. Science. B, 2014

BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage.

Schoenfeld AR et al.

Molecular and Cellular Biology, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."