Varaico: Literature-Extracted Genetic Variants

Gene:USP18
Variant:p.C64S
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USP18

NM_017414.4:p.C64S

Associated Papers

USP18 deubiquitinates and stabilizes SOX9 to promote the stemness and malignant progression of glioblastoma.

Liu Z et al.

Cell Death Discovery, 2025

Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41.

Bonacci T et al.

Biorxiv : the Preprint Server for Biology, 2024

Type I interferon regulation by USP18 is a key vulnerability in cancer.

Jové V et al.

Iscience, 2024

The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication.

Lin C et al.

Viruses, 2024

Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18.

Miyauchi S et al.

Cell Reports, 2023

Regulation of STING activity in DNA sensing by ISG15 modification.

Lin C et al.

Cell Reports, 2023

A partial form of inherited human USP18 deficiency underlies infection and inflammation.

Martin-Fernandez M et al.

The Journal of Experimental Medicine, 2022

ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.

Osei Kuffour E et al.

Mbio, 2019

USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.

Yang Z et al.

Scientific Reports, 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."