Varaico: Literature-Extracted Genetic Variants

Gene:USP21
Variant:p.S74*
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USP21

NM_001014443.3:p.S74*

Associated Papers

USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation.

Song T et al.

Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2026

Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells.

Zhang H et al.

Cell Reports. Medicine, 2025

Disulfiram impairs USP21-mediated MOF-K257 deubiquitination to inhibit esophageal squamous cell carcinoma progression.

Yang L et al.

Cancer Letters, 2024

USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling.

Guo J et al.

Oncogenesis, 2024

Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases.

Zhao Z et al.

Journal of the American Chemical Society, 2023

The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth.

Li W et al.

Cell Death & Disease, 2018

Mechanism and regulation of the Lys6-selective deubiquitinase USP30.

Gersch M et al.

Nature Structural & Molecular Biology, 2017

Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth.

Liu J et al.

Nature Communications, 2017

Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3.

Zhang J et al.

The Journal of Biological Chemistry, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."