Associated Papers
USP7 sustains hematopoietic stem cell homeostasis partially via PU.1 stabilization.
Shan H et al.
International Journal of Biological Sciences, 2026
Selective USP7 Inhibition Synergizes with MEK1/2 Inhibitor to Enhance Immune Responses and Potentiate Anti-PD-1 Therapy in NRAS-Mutant Melanoma.
Su L et al.
The Journal of Investigative Dermatology, 2025
RNF4 and USP7 coordinate spatial regulation of SLX4 stability within the PML nuclear bodies.
Jung E et al.
Nucleic Acids Research, 2025
USP15 inhibits hypoxia-induced IL-6 signaling by deubiquitinating and stabilizing MeCP2.
Zhang ZT et al.
The Febs Journal, 2025
USP7 protects TFEB from proteasome-mediated degradation.
Keshri S et al.
Cell Reports, 2024
USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion.
Tang K et al.
The Journal of Biological Chemistry, 2024
PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer.
Peng L et al.
Cell Death & Disease, 2024
USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
Zhao B et al.
Cell Reports, 2024
USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.
Liu X et al.
Molecular Oncology, 2024
Structural and functional characterization of USP47 reveals a hot spot for inhibitor design.
Shin SC et al.
Communications Biology, 2023
De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity.
Liu J et al.
Oncogene, 2023
EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO.
Barbeito P et al.
Frontiers in Cell and Developmental Biology, 2023
USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7.
Lee SH et al.
Plos One, 2023
USP7 substrates identified by proteomics analysis reveal the specificity of USP7.
Nie L et al.
Genes & Development, 2022
USP7 regulates the ERK1/2 signaling pathway through deubiquitinating Raf-1 in lung adenocarcinoma.
Park HB et al.
Cell Death & Disease, 2022
UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.
Huang Q et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2022
IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myeloma.
Liu M et al.
International Journal of Biological Sciences, 2022
The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair.
Wilson P et al.
Journal of Cell Science, 2021
Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis.
Su D et al.
Nucleic Acids Research, 2021
DNA Polymerase ι Interacts with Both the TRAF-like and UBL1-2 Domains of USP7.
Ashton NW et al.
Journal of Molecular Biology, 2021
Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.
Pluciennik A et al.
The Journal of Clinical Investigation, 2021
USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway.
Zhang T et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
Deubiquitylase USP7 regulates human terminal erythroid differentiation by stabilizing GATA1.
Liang L et al.
Haematologica, 2019
Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease.
Rawat R et al.
Current Opinion in Cell Biology, 2019
USP7 Regulates Cytokinesis through FBXO38 and KIF20B.
Georges A et al.
Scientific Reports, 2019
BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.
Biswas K et al.
Nature Communications, 2018
Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation.
Özen A et al.
Structure (london, England : 1993), 2018
USP7 small-molecule inhibitors interfere with ubiquitin binding.
Kategaya L et al.
Nature, 2017
DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.
Hernández-Pérez S et al.
Oncogene, 2017
Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.
Jiang L et al.
The Journal of Biological Chemistry, 2017
Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis.
Wang Q et al.
The Journal of Clinical Investigation, 2016
USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation.
Mungamuri SK et al.
Cell Reports, 2016
USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.
Zlatanou A et al.
Oncogene, 2016
STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation.
Ye M et al.
Oncotarget, 2015
USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder.
Hao YH et al.
Molecular Cell, 2015
HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response.
Lim KH et al.
Scientific Reports, 2015
Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.
Cheng J et al.
Nature Communications, 2015
Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).
Ding X et al.
Plos One, 2015
The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7.
Zemp I et al.
The Journal of Biological Chemistry, 2014
Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis.
He J et al.
The Journal of Biological Chemistry, 2014
Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization.
Reddy BA et al.
Molecular Cell, 2014
USP7 controls Chk1 protein stability by direct deubiquitination.
Alonso-de Vega I et al.
Cell Cycle (georgetown, Tex.), 2014
Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.
Sarkari F et al.
The Journal of Biological Chemistry, 2013
USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair.
Khoronenkova SV et al.
Nucleic Acids Research, 2013
Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.
Sarkari F et al.
Journal of Molecular Biology, 2010
USP7/HAUSP promotes the sequence-specific DNA binding activity of p53.
Sarkari F et al.
Plos One, 2010
Regulation of the Polycomb protein RING1B ubiquitination by USP7.
de Bie P et al.
Biochemical and Biophysical Research Communications, 2010
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.
Maertens GN et al.
The Embo Journal, 2010