Varaico: Literature-Extracted Genetic Variants

Gene:USP8
Variant:p.C786S
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USP8

NM_005154.5:p.C786S

Associated Papers

Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.

Tey PY et al.

The Journal of Cell Biology, 2025

Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.

Tey PY et al.

Biorxiv : the Preprint Server for Biology, 2024

Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.

Hans F et al.

The Journal of Biological Chemistry, 2020

Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.

Kim Y et al.

Oncogene, 2018

USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-Dependent Protein Levels.

Kerrisk Campbell M et al.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2018

Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8.

Scudder SL et al.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2014

USP8 controls the trafficking and sorting of lysosomal enzymes.

MacDonald E et al.

Traffic (copenhagen, Denmark), 2014

UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.

Hans F et al.

The Journal of Biological Chemistry, 2014

USP8 modulates ubiquitination of LRIG1 for Met degradation.

Oh YM et al.

Scientific Reports, 2014

Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing.

De Ceuninck L et al.

Journal of Cell Science, 2013

Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel.

Zhou R et al.

The Journal of Biological Chemistry, 2013

Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1.

Balut CM et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2011

Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.

Hasdemir B et al.

The Journal of Biological Chemistry, 2009

The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.

Row PE et al.

The Journal of Biological Chemistry, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."