Associated Papers
Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations.
Feng X et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila.
Humphries AC et al.
Elife, 2020
Vangl2 interaction plays a role in the proteasomal degradation of Prickle2.
Nagaoka T et al.
Scientific Reports, 2019
Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.
El-Hassan AR et al.
Mammalian Genome : Official Journal of the International Mammalian Genome Society, 2018
The planar cell polarity protein Vangl2 is required for retinal axon guidance.
Leung V et al.
Developmental Neurobiology, 2016
Expanding the mutational spectrum associated to neural tube defects: literature revision and description of novel VANGL1 mutations.
Merello E et al.
Birth Defects Research. Part A, Clinical and Molecular Teratology, 2015
Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.
Murdoch JN et al.
Disease Models & Mechanisms, 2014
Independent mutations at Arg181 and Arg274 of Vangl proteins that are associated with neural tube defects in humans decrease protein stability and impair membrane targeting.
Iliescu A et al.
Biochemistry, 2014
Identification of novel CELSR1 mutations in spina bifida.
Lei Y et al.
Plos One, 2014
Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes.
Belotti E et al.
Plos One, 2012
Contribution of VANGL2 mutations to isolated neural tube defects.
Kibar Z et al.
Clinical Genetics, 2011
A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.
Guyot MC et al.
Developmental Dynamics : an Official Publication of the American Association of Anatomists, 2011
Transmembrane topology of mammalian planar cell polarity protein Vangl1.
Iliescu A et al.
Biochemistry, 2011
VANGL2 mutations in human cranial neural-tube defects.
Lei YP et al.
The New England Journal of Medicine, 2010
Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.
Gravel M et al.
Biochemistry, 2010
Genetic interaction between members of the Vangl family causes neural tube defects in mice.
Torban E et al.
Proceedings of the National Academy of Sciences of the United States of America, 2008
Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.
Murdoch JN et al.
Human Molecular Genetics, 2001
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.
Kibar Z et al.
Nature Genetics, 2001