Varaico: Literature-Extracted Genetic Variants

Gene:VCP
Variant:p.K251T
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VCP

NM_007126.5:p.K251T

Associated Papers

Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97.

Hänzelmann P et al.

Structure (london, England : 1993), 2016

Altered intersubunit communication is the molecular basis for functional defects of pathogenic p97 mutants.

Tang WK et al.

The Journal of Biological Chemistry, 2013

ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity.

Song C et al.

The Journal of Biological Chemistry, 2003

Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities.

Wang Q et al.

Biochemical and Biophysical Research Communications, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."