Associated Papers
Widespread anticoagulant resistance in house mice (Mus musculus musculus) linked to the Tyr139Phe mutation in the Czech Republic.
Frankova M et al.
Scientific Reports, 2025
Large-scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations.
Krijger IM et al.
Pest Management Science, 2023
Vkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats.
Yiğit N et al.
Peerj, 2023
Investigation of anticoagulant rodenticide resistance induced by Vkorc1 mutations in rodents in Lebanon.
Rached A et al.
Scientific Reports, 2022
The screening for anticoagulant rodenticide gene VKORC1 polymorphism in the rat Rattus norvegicus, Rattus tanezumi and Rattus losea in Hong Kong.
Huang EYY et al.
Scientific Reports, 2022
Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management.
Damin-Pernik M et al.
Pesticide Biochemistry and Physiology, 2022
VKORC1 mutations in rodent populations of a tropical city-state as an indicator of anticoagulant rodenticide resistance.
Chua C et al.
Scientific Reports, 2022
The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus).
Takeda K et al.
Pesticide Biochemistry and Physiology, 2021
Establishment of the Variation of Vitamin K Status According to Vkorc1 Point Mutations Using Rat Models.
Debaux JV et al.
Nutrients, 2019
The potential of VKORC1 polymorphisms in Mustelidae for evolving anticoagulant resistance through selection along the food chain.
Stöck M et al.
Plos One, 2019
Missense mutation of VKORC1 leads to medial arterial calcification in rats.
Michaux A et al.
Scientific Reports, 2018
Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase.
Rishavy MA et al.
Blood, 2018
Elevated difenacoum metabolism is involved in the difenacoum-resistant phenotype observed in Berkshire rats homozygous for the L120Q mutation in the vitamin K epoxide reductase complex subunit 1 (Vkorc1) gene.
Boitet M et al.
Pest Management Science, 2018
Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition.
Shen G et al.
Journal of Thrombosis and Haemostasis : Jth, 2018
Adaptative evolution of the Vkorc1 gene in Mus musculus domesticus is influenced by the selective pressure of anticoagulant rodenticides.
Goulois J et al.
Ecology and Evolution, 2017
Study of the efficiency of anticoagulant rodenticides to control Mus musculus domesticus introgressed with Mus spretus Vkorc1.
Goulois J et al.
Pest Management Science, 2017
Warfarin and vitamin K compete for binding to Phe55 in human VKOR.
Czogalla KJ et al.
Nature Structural & Molecular Biology, 2017
Evidence of a target resistance to antivitamin K rodenticides in the roof rat Rattus rattus: identification and characterisation of a novel Y25F mutation in the Vkorc1 gene.
Goulois J et al.
Pest Management Science, 2016
Distribution of anticoagulant rodenticide resistance in Rattus norvegicus in the Netherlands according to Vkorc1 mutations.
Meerburg BG et al.
Pest Management Science, 2014
Identification of VKORC1 genotype leading to resistance to tecarfarin.
Matagrin B et al.
Journal of Clinical Pharmacology, 2014
Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.
Tie JK et al.
The Journal of Biological Chemistry, 2014
Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling.
Müller E et al.
Bmc Genetics, 2014
A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay.
Fregin A et al.
Journal of Thrombosis and Haemostasis : Jth, 2013
A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.
Tanaka KD et al.
The Journal of Veterinary Medical Science, 2013
New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations.
Matagrin B et al.
Febs Open Bio, 2013
VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity.
Hodroge A et al.
Journal of Thrombosis and Haemostasis : Jth, 2012
Human vitamin K epoxide reductase and its bacterial homologue have different membrane topologies and reaction mechanisms.
Tie JK et al.
The Journal of Biological Chemistry, 2012
Vitamin K requirement and reproduction in bromadiolone-resistant Norway rats.
Jacob J et al.
Pest Management Science, 2012
Distribution of VKORC1 single nucleotide polymorphism in wild Rattus norvegicus in France.
Grandemange A et al.
Pest Management Science, 2010
Structure of a bacterial homologue of vitamin K epoxide reductase.
Li W et al.
Nature, 2010
Comparative and veterinary pharmacogenomics.
Mosher CM et al.
Handbook of Experimental Pharmacology, 2010
Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats.
Grandemange A et al.
Pharmacogenetics and Genomics, 2009
Novel mutations in the VKORC1 gene of wild rats and mice--a response to 50 years of selection pressure by warfarin?
Rost S et al.
Bmc Genetics, 2009
Building individualized medicine: prevention of adverse reactions to warfarin therapy.
Krynetskiy E et al.
The Journal of Pharmacology and Experimental Therapeutics, 2007
Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo.
Ishizuka M et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2007
The genetic basis of resistance to anticoagulants in rodents.
Pelz HJ et al.
Genetics, 2005