Associated Papers
Incidence of Vkorc1 gene mutations in brown rat (Rattus norvegicus) populations from downtown Madrid and their role in resistance to anticoagulant rodenticide: Implications for rodenticide management.
Bermejo-Nogales A et al.
Ecotoxicology and Environmental Safety, 2026
Rapid population expansion drives the widespread spread of a dominant anticoagulant-resistance Vkorc1 allele in Asian house rats (Rattus tanezumi) across China.
Sun T et al.
Pest Management Science, 2025
Widespread anticoagulant resistance in house mice (Mus musculus musculus) linked to the Tyr139Phe mutation in the Czech Republic.
Frankova M et al.
Scientific Reports, 2025
A survey of VKORC1 missense mutations in eleven Italian islands reveals widespread rodenticide resistance in house mice.
Gallozzi F et al.
The Science of the Total Environment, 2024
Widespread distribution of rodenticide resistance-conferring mutations in the Vkorc1 gene among house mouse populations in Portuguese Macaronesian islands and Iberian Atlantic areas.
Carromeu-Santos A et al.
The Science of the Total Environment, 2023
Large-scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations.
Krijger IM et al.
Pest Management Science, 2023
Vkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats.
Yiğit N et al.
Peerj, 2023
Investigation of anticoagulant rodenticide resistance induced by Vkorc1 mutations in rodents in Lebanon.
Rached A et al.
Scientific Reports, 2022
The screening for anticoagulant rodenticide gene VKORC1 polymorphism in the rat Rattus norvegicus, Rattus tanezumi and Rattus losea in Hong Kong.
Huang EYY et al.
Scientific Reports, 2022
Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management.
Damin-Pernik M et al.
Pesticide Biochemistry and Physiology, 2022
VKORC1 mutations in rodent populations of a tropical city-state as an indicator of anticoagulant rodenticide resistance.
Chua C et al.
Scientific Reports, 2022
The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus).
Takeda K et al.
Pesticide Biochemistry and Physiology, 2021
The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population.
Bader L et al.
The Pharmacogenomics Journal, 2020
Establishment of the Variation of Vitamin K Status According to Vkorc1 Point Mutations Using Rat Models.
Debaux JV et al.
Nutrients, 2019
The potential of VKORC1 polymorphisms in Mustelidae for evolving anticoagulant resistance through selection along the food chain.
Stöck M et al.
Plos One, 2019
Low warfarin resistance frequency in Norway rats in two cities in China after 30 years of usage of anticoagulant rodenticides.
Ma X et al.
Pest Management Science, 2018
Missense mutation of VKORC1 leads to medial arterial calcification in rats.
Michaux A et al.
Scientific Reports, 2018
Elevated difenacoum metabolism is involved in the difenacoum-resistant phenotype observed in Berkshire rats homozygous for the L120Q mutation in the vitamin K epoxide reductase complex subunit 1 (Vkorc1) gene.
Boitet M et al.
Pest Management Science, 2018
Study of the efficiency of anticoagulant rodenticides to control Mus musculus domesticus introgressed with Mus spretus Vkorc1.
Goulois J et al.
Pest Management Science, 2017
Vkorc1 sequencing suggests anticoagulant resistance in rats in New Zealand.
Cowan PE et al.
Pest Management Science, 2017
Evidence of a target resistance to antivitamin K rodenticides in the roof rat Rattus rattus: identification and characterisation of a novel Y25F mutation in the Vkorc1 gene.
Goulois J et al.
Pest Management Science, 2016
Distribution of anticoagulant rodenticide resistance in Rattus norvegicus in the Netherlands according to Vkorc1 mutations.
Meerburg BG et al.
Pest Management Science, 2014
Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling.
Müller E et al.
Bmc Genetics, 2014
Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay.
Bevans CG et al.
Biochimica Et Biophysica Acta, 2013
A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay.
Fregin A et al.
Journal of Thrombosis and Haemostasis : Jth, 2013
Vkorc1 variation in house mice during warfarin and difenacoum field trials.
Endepols S et al.
Pest Management Science, 2013
A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.
Tanaka KD et al.
The Journal of Veterinary Medical Science, 2013
New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations.
Matagrin B et al.
Febs Open Bio, 2013
Vitamin K requirement and reproduction in bromadiolone-resistant Norway rats.
Jacob J et al.
Pest Management Science, 2012
Distribution and frequency of VKORC1 sequence variants conferring resistance to anticoagulants in Mus musculus.
Pelz HJ et al.
Pest Management Science, 2012
Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world mice.
Song Y et al.
Current Biology : Cb, 2011
Distribution of VKORC1 single nucleotide polymorphism in wild Rattus norvegicus in France.
Grandemange A et al.
Pest Management Science, 2010
Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats.
Grandemange A et al.
Pharmacogenetics and Genomics, 2009
Novel mutations in the VKORC1 gene of wild rats and mice--a response to 50 years of selection pressure by warfarin?
Rost S et al.
Bmc Genetics, 2009
Characterization of bromadiolone resistance in a danish strain of Norway rats, Rattus norvegicus, by hepatic gene expression profiling of genes involved in vitamin K-dependent gamma-carboxylation.
Markussen MD et al.
Journal of Biochemical and Molecular Toxicology, 2007
The genetic basis of resistance to anticoagulants in rodents.
Pelz HJ et al.
Genetics, 2005
Vitamin K epoxide reductase: homology, active site and catalytic mechanism.
Goodstadt L et al.
Trends in Biochemical Sciences, 2004
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Rost S et al.
Nature, 2004
Polymorphism in vkorc1 Gene of Natal Multimammate Mice, Mastomys natalensis, in Tanzania.
Gryseels S et al.
The Journal of Heredity, 0