Associated Papers
Detection of Vkorc1 single nucleotide polymorphisms indicates the presence of anticoagulant rodenticide resistance in Australia's introduced rats†.
Gorbould AF et al.
Pest Management Science, 2025
Widespread anticoagulant resistance in house mice (Mus musculus musculus) linked to the Tyr139Phe mutation in the Czech Republic.
Frankova M et al.
Scientific Reports, 2025
Synergy of Mutation-Induced Effects in Human Vitamin K Epoxide Reductase: Perspectives and Challenges for Allo-Network Modulator Design.
Botnari M et al.
International Journal of Molecular Sciences, 2024
Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state.
Li S et al.
Blood Advances, 2023
Vkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats.
Yiğit N et al.
Peerj, 2023
Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management.
Damin-Pernik M et al.
Pesticide Biochemistry and Physiology, 2022
The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus).
Takeda K et al.
Pesticide Biochemistry and Physiology, 2021
Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.
Chiasson MA et al.
Elife, 2020
Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition.
Shen G et al.
Journal of Thrombosis and Haemostasis : Jth, 2018
Structural Modeling Insights into Human VKORC1 Phenotypes.
Czogalla KJ et al.
Nutrients, 2015
Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling.
Müller E et al.
Bmc Genetics, 2014
Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces.
Czogalla KJ et al.
Blood, 2013
VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity.
Hodroge A et al.
Journal of Thrombosis and Haemostasis : Jth, 2012
Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world mice.
Song Y et al.
Current Biology : Cb, 2011
Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment.
Watzka M et al.
Journal of Thrombosis and Haemostasis : Jth, 2011
VKORC1 mutations in patients with partial resistance to phenprocoumon.
Schmeits PC et al.
British Journal of Haematology, 2010
Structure of a bacterial homologue of vitamin K epoxide reductase.
Li W et al.
Nature, 2010
A new VKORC1 mutation leading to an isolated resistance to fluindione.
Peoc'h K et al.
British Journal of Haematology, 2009
Novel mutations in the VKORC1 gene of wild rats and mice--a response to 50 years of selection pressure by warfarin?
Rost S et al.
Bmc Genetics, 2009
[Resistance to coumarin derivatives due to mutated vitamin-K enzyme].
Hermans MH et al.
Nederlands Tijdschrift Voor Geneeskunde, 2009
The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects.
Umemura K et al.
Journal of Thrombosis and Haemostasis : Jth, 2008
A new VKORC1 allelic variant (p.Trp59Arg) in a patient with partial resistance to acenocoumarol and phenprocoumon.
Wilms EB et al.
Journal of Thrombosis and Haemostasis : Jth, 2008
Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1.
Van Horn WD
Critical Reviews in Biochemistry and Molecular Biology, 0