Associated Papers
Widespread anticoagulant resistance in house mice (Mus musculus musculus) linked to the Tyr139Phe mutation in the Czech Republic.
Frankova M et al.
Scientific Reports, 2025
Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state.
Li S et al.
Blood Advances, 2023
Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management.
Damin-Pernik M et al.
Pesticide Biochemistry and Physiology, 2022
Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.
Chiasson MA et al.
Elife, 2020
32870157 (PubMed )
Supplement: elife-58026-supp3.docx
Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition.
Shen G et al.
Journal of Thrombosis and Haemostasis : Jth, 2018
Evidence of a target resistance to antivitamin K rodenticides in the roof rat Rattus rattus: identification and characterisation of a novel Y25F mutation in the Vkorc1 gene.
Goulois J et al.
Pest Management Science, 2016
Structural Modeling Insights into Human VKORC1 Phenotypes.
Czogalla KJ et al.
Nutrients, 2015
Identification of VKORC1 genotype leading to resistance to tecarfarin.
Matagrin B et al.
Journal of Clinical Pharmacology, 2014
Pharmacogenetics in Jewish populations.
Yang Y et al.
Drug Metabolism and Drug Interactions, 2014
Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces.
Czogalla KJ et al.
Blood, 2013
VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity.
Hodroge A et al.
Journal of Thrombosis and Haemostasis : Jth, 2012
Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment.
Watzka M et al.
Journal of Thrombosis and Haemostasis : Jth, 2011
Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1.
Harrington DJ et al.
Journal of Thrombosis and Haemostasis : Jth, 2008
Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans.
Bodin L et al.
Journal of Thrombosis and Haemostasis : Jth, 2008
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