Associated Papers
Convergent molecular pathways to inherited Parkinson's disease.
Pfeffer SR
Current Opinion in Cell Biology, 2026
Generation of two isogenic control iPSC lines (LCSBi001-A-2 and LCSBi001-A-3) from a Parkinson's disease patient line (LCSBi001-A) carrying the pathogenic VPS35 p.D620N mutation.
Boumpoureka I et al.
Stem Cell Research, 2026
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif.
Waschbüsch D et al.
Structure (london, England : 1993), 2026
In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of α-synuclein Toxicity in Dopamine Neurons.
Shonai D et al.
Biorxiv : the Preprint Server for Biology, 2026
The Assessment of RAB32 p.Ser71Arg Variant Prevalence in Parkinson's Disease Across Selected African, European, and South American Cohorts.
Olszewska DA et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2026
Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders.
Lu J et al.
Autophagy, 2026
Autophagy-Lysosome Pathway Dysfunction in Neurodegeneration and Cancer: Mechanisms and Therapeutic Opportunities.
Du M et al.
International Journal of Molecular Sciences, 2025
Synaptic Vesicle Disruption in Parkinson's Disease: Dual Roles of α-Synuclein and Emerging Therapeutic Targets.
Treviño M et al.
Brain Sciences, 2025
LRRK2 as a Potential Disease-Modifying Target in Sporadic Parkinson's Disease.
Lang AE et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2025
WES-Based Screening of a Swedish Patient Series with Parkinson's Disease.
Kafantari E et al.
Genes, 2025
E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy.
Wang H et al.
Medcomm, 2025
JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulation.
Bonet-Ponce L et al.
The Journal of Cell Biology, 2025
VPS35 mutation inhibits PINK1/parkin-mediated mitophagy via increased LRRK2 kinase activity.
Manders L et al.
Brain : a Journal of Neurology, 2025
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.
Buck SA et al.
Acta Neuropathologica, 2025
Synaptojanin-1 supports VPS35-dependent trafficking of dopamine D2 autoreceptors at presynaptic terminals.
Kumar N et al.
Research Square, 2025
Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.
Akçimen F et al.
Brain : a Journal of Neurology, 2025
Inborn errors of canonical autophagy in neurodegenerative diseases.
Freisem D et al.
Human Molecular Genetics, 2025
Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils.
Vanderperre B et al.
Communications Biology, 2025
Dystonia-predominant VPS35-related parkinson's disease: diagnostic challenges and the role of Levodopa response in unmasking genetic etiology.
Tan C et al.
Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025
Functional and Structural Characterization of LRRK2 p.V1447L in Parkinson's Disease.
Pratuseviciute N et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2025
Regulation of LRRK2 activity by metabolic stress and heavy metal exposure.
Kentros M et al.
Brain Research, 2025
Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer's disease mouse model.
Ramonet D et al.
Acta Neuropathologica Communications, 2025
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif.
Waschbüsch D et al.
Biorxiv : the Preprint Server for Biology, 2025
Genetic testing for Parkinson's disease in Israel: Insights from the Rostock Parkinson's Disease (ROPAD) study.
Anis S et al.
Parkinsonism & Related Disorders, 2025
Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation.
Antón-Plágaro C et al.
Nature Communications, 2025
The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance.
Lange LM et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background.
Koros C et al.
Biomedicines, 2025
Genetics of Parkinson's Disease: From Causes to Treatment.
Westenberger A et al.
Cold Spring Harbor Perspectives in Medicine, 2025
Inflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2.
Dikovskaya D et al.
Embo Reports, 2025
The Parkinson Disease-Associated Mutant DNAJC13(N855S) Leads to Its Accelerated Degradation and Negatively Affects Macroautophagy and Retromer Complex-Mediated Dynamics.
Stein A et al.
Journal of Cellular Physiology, 2025
Leucine-Rich Repeat Kinase 2: Pathways to Parkinson's Disease.
Pfeffer SR et al.
Cold Spring Harbor Perspectives in Medicine, 2025
Role of LRRK2 in axonal transport and Parkinson's disease.
Twellsieck B et al.
The Biochemical Journal, 2025
Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies.
Buck SA et al.
Biorxiv : the Preprint Server for Biology, 2025
LRRK2-mediated mitochondrial dysfunction in Parkinson's disease.
Buck SA et al.
The Biochemical Journal, 2025
Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson's Disease.
Lucchesi M et al.
International Journal of Molecular Sciences, 2025
Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition.
Kamesh A et al.
Npj Parkinson's Disease, 2025
The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria-ER membranes.
Barbuti PA et al.
Npj Parkinson's Disease, 2025
Retromer promotes the lysosomal turnover of mtDNA.
Kakanj P et al.
Science Advances, 2025
LRRK2, lysosome damage, and Parkinson's disease.
Bentley-DeSousa A et al.
Current Opinion in Cell Biology, 2025
Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies.
Morderer D et al.
Molecular Neurodegeneration, 2025
γ-secretase facilitates retromer-mediated retrograde transport.
Takeo Y et al.
Journal of Cell Science, 2025
Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.
Akçimen F et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson's disease by using molecular docking, molecular dynamic simulation, and cellular model.
Jiang M et al.
Frontiers in Aging Neuroscience, 2025
The crucial role of VPS35 and SHH in Parkinson's disease: Understanding the mechanisms behind the neurodegenerative disorder.
Bhardwaj K et al.
Brain Research, 2024
Uncovering the genetic basis of Parkinson's disease globally: from discoveries to the clinic.
Lim SY et al.
The Lancet. Neurology, 2024
Genetic-based diagnostics of Parkinson's disease and other Parkinsonian syndromes.
Somerville EN et al.
Expert Review of Molecular Diagnostics, 2024
Characterization of Dnajc12 knockout mice, a model of hypodopaminergia.
Deng IB et al.
Biorxiv : the Preprint Server for Biology, 2024
Assembly and fission of tubular carriers mediating protein sorting in endosomes.
Gopaldass N et al.
Nature Reviews. Molecular Cell Biology, 2024