Associated Papers
An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine.
Asmi S et al.
Ageing Research Reviews, 2026
VPS35 and retromer dysfunction in Parkinson's disease.
Rowlands J et al.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2024
VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease.
Chen X et al.
Molecular Neurodegeneration, 2023
Genetic Evidence for Endolysosomal Dysfunction in Parkinson's Disease: A Critical Overview.
Yahya V et al.
International Journal of Molecular Sciences, 2023
Understanding the contributions of VPS35 and the retromer in neurodegenerative disease.
Williams ET et al.
Neurobiology of Disease, 2022
Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases.
Yoshida S et al.
Frontiers in Aging Neuroscience, 2022
Retromer dependent changes in cellular homeostasis and Parkinson's disease.
Yang Z et al.
Essays in Biochemistry, 2021
Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.
Ding Y et al.
Cells, 2021
The Role of VPS35 in the Pathobiology of Parkinson's Disease.
Sassone J et al.
Cellular and Molecular Neurobiology, 2021
An update on cellular and molecular determinants of Parkinson's disease with emphasis on the role of the retromer complex.
Macías-Calvio V et al.
Journal of Neuroscience Research, 2021
Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models.
Abe T et al.
Frontiers in Neurology, 2021
Mechanisms of VPS35-Mediated Neurodegeneration in Parkinson's Disease.
Sargent D et al.
International Review of Movement Disorders, 2021
VPS35, the core component of the retromer complex, and Parkinson's disease.
Luo AD et al.
Ibrain, 2021
Rare VPS35 A320V Variant in Taiwanese Parkinson's Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology.
Wu YR et al.
Brain Sciences, 2020
Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N.
Bono K et al.
Molecular Brain, 2020
The vicious cycle between α-synuclein aggregation and autophagic-lysosomal dysfunction.
Bellomo G et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2020
Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells.
Hu X et al.
Stem Cells International, 2020
Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.
Chen X et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Contributions of VPS35 Mutations to Parkinson's Disease.
Rahman AA et al.
Neuroscience, 2019
VPS35-Based Approach: A Potential Innovative Treatment in Parkinson's Disease.
Eleuteri S et al.
Frontiers in Neurology, 2019
Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.
Williams ET et al.
Human Molecular Genetics, 2018
The functional roles of retromer in Parkinson's disease.
Cui Y et al.
Febs Letters, 2018
Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease.
Zeng XS et al.
Frontiers in Aging Neuroscience, 2018
Role of the VPS35 D620N mutation in Parkinson's disease.
Mohan M et al.
Parkinsonism & Related Disorders, 2017
VPS35, the Retromer Complex and Parkinson's Disease.
Williams ET et al.
Journal of Parkinson's Disease, 2017
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.
Hernandez DG et al.
Journal of Neurochemistry, 2016
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation.
Follett J et al.
The Journal of Biological Chemistry, 2016
Launching the movement disorders society genetic mutation database (MDSGene).
Lill CM et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2016
Vacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of Disease.
Gambardella S et al.
Frontiers in Neuroscience, 2016
VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.
Malik BR et al.
Human Molecular Genetics, 2015
VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.
Tang FL et al.
Cell Reports, 2015
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.
Reitz C
Molecular Genetics and Genomics : Mgg, 2015
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
Dhungel N et al.
Neuron, 2015
Application of next-generation sequencing technologies in Neurology.
Jiang T et al.
Annals of Translational Medicine, 2014
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.
Miura E et al.
Neurobiology of Disease, 2014
In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila.
Wang HS et al.
Molecular Brain, 2014
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
Tsika E et al.
Human Molecular Genetics, 2014
Update on novel familial forms of Parkinson's disease and multiple system atrophy.
Fujioka S et al.
Parkinsonism & Related Disorders, 2014
The VPS35 gene and Parkinson's disease.
Deng H et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2013
Monogenic Parkinson's disease and parkinsonism: clinical phenotypes and frequencies of known mutations.
Puschmann A
Parkinsonism & Related Disorders, 2013
Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease.
Nuytemans K et al.
Neurology, 2013
VPS35 mutation in Japanese patients with typical Parkinson's disease.
Ando M et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2012
VPS35 mutation in Chinese Han patients with late-onset Parkinson's disease.
Deng H et al.
European Journal of Neurology, 2012
VPS35 mutations in Parkinson disease.
Vilariño-Güell C et al.
American Journal of Human Genetics, 2011