Associated Papers
Nuclear functions regulated by the VRK1 kinase.
Lazo PA
Nucleus (austin, Tex.), 2024
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy.
Campos-Díaz A et al.
Journal of Molecular Medicine (berlin, Germany), 2024
VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma.
Shields JA et al.
Cancer Research, 2022
VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system.
So J et al.
Jci Insight, 2022
Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia.
Morejon-Garcia P et al.
Neurology. Genetics, 2021
The human VRK1 chromatin kinase in cancer biology.
Campillo-Marcos I et al.
Cancer Letters, 2021
VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy.
Marcos AT et al.
Annals of Clinical and Translational Neurology, 2020
Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells.
Yokobori K et al.
Bioscience Reports, 2020
VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes.
Martín-Doncel E et al.
Scientific Reports, 2019
VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage.
Monsalve DM et al.
Biochimica Et Biophysica Acta, 2016
The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-β precursor protein-dependent mechanism.
Vinograd-Byk H et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2015
VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage.
López-Sánchez I et al.
Febs Letters, 2014
Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications.
Sanz-García M et al.
Journal of Proteomics, 2011
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.
Valbuena A et al.
Plos One, 2011
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities.
Sanz-García M et al.
Molecular & Cellular Proteomics : Mcp, 2008
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.
Vega FM et al.
Molecular and Cellular Biology, 2004
Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK.
Sevilla A et al.
The Journal of Biological Chemistry, 2004