Associated Papers
WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.
Saha B et al.
Journal of Cell Science, 2022
The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis.
Lin SC et al.
Biomedicines, 2022
With-No-Lysine Kinase 1 (WNK1) Augments TRPV4 Function in the Aldosterone-Sensitive Distal Nephron.
Tomilin VN et al.
Cells, 2021
Cell-specific regulation of L-WNK1 by dietary K.
Webb TN et al.
American Journal of Physiology. Renal Physiology, 2016
Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.
Mendes AI et al.
The Journal of Biological Chemistry, 2010
Domains of WNK1 kinase in the regulation of ROMK1.
Wang HR et al.
American Journal of Physiology. Renal Physiology, 2008
WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.
Oh E et al.
The Journal of Biological Chemistry, 2007
Intersectin links WNK kinases to endocytosis of ROMK1.
He G et al.
The Journal of Clinical Investigation, 2007
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
Moriguchi T et al.
The Journal of Biological Chemistry, 2005
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.
Xu BE et al.
The Journal of Biological Chemistry, 2005
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
Lee BH et al.
Molecular Cell, 2004
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.
Xu BE et al.
The Journal of Biological Chemistry, 2004
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.
Xu BE et al.
The Journal of Biological Chemistry, 2002
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.
Xu B et al.
The Journal of Biological Chemistry, 2000
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