Associated Papers
WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth.
Duan S et al.
Nature Communications, 2025
B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.
Hayward DA et al.
The Journal of Experimental Medicine, 2023
The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis.
Lin SC et al.
Biomedicines, 2022
Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders.
Kim Y et al.
Cellular and Molecular Gastroenterology and Hepatology, 2020
Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway.
Sato A et al.
Plos One, 2018
With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.
Mercado A et al.
American Journal of Physiology. Cell Physiology, 2016
WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Chávez-Canales M et al.
Hypertension (dallas, Tex. : 1979), 2014
SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.
Thastrup JO et al.
The Biochemical Journal, 2012
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.
Yang CL et al.
The Journal of Clinical Investigation, 2007
WNK4 kinase is a negative regulator of K+-Cl- cotransporters.
Garzón-Muvdi T et al.
American Journal of Physiology. Renal Physiology, 2007
[Clinical significance of thiazide-sensitive Na-Cl cotransporter gene by mutational analysis].
Yasujima M
Rinsho Byori. the Japanese Journal of Clinical Pathology, 2007
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.
Zagórska A et al.
The Journal of Cell Biology, 2007
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
Moriguchi T et al.
The Journal of Biological Chemistry, 2005
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
Vitari AC et al.
The Biochemical Journal, 2005
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport.
Yang CL et al.
The Journal of Clinical Investigation, 2005
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.
Vitari AC et al.
The Biochemical Journal, 2004
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.
Xu B et al.
The Journal of Biological Chemistry, 2000