Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM3_ESM.xlsx › Table_S14
Expression of the kidney anion exchanger 1 affects WNK4 and SPAK phosphorylation and results in claudin-4 phosphorylation.
Lashhab R et al.
Heliyon, 2023
The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis.
Lin SC et al.
Biomedicines, 2022
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.
Maruyama J et al.
Scientific Reports, 2016
The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride.
Bazúa-Valenti S et al.
Journal of the American Society of Nephrology : Jasn, 2015
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Bazúa-Valenti S et al.
American Journal of Physiology. Cell Physiology, 2015
Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
Na T et al.
Biochemical and Biophysical Research Communications, 2012
Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway.
Lai L et al.
Pflugers Archiv : European Journal of Physiology, 2012
WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.
Zhuang J et al.
American Journal of Physiology. Renal Physiology, 2011
Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF.
Shaharabany M et al.
The Febs Journal, 2008
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.
Jiang Y et al.
American Journal of Physiology. Renal Physiology, 2007
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells.
Cai H et al.
Kidney International, 2006
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
Vitari AC et al.
The Biochemical Journal, 2005
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