Associated Papers
Familial Hyperkalemic Hypertension.
Cornelius RJ et al.
Comprehensive Physiology, 2024
Insights into the diverse mechanisms and effects of variant CUL3-induced familial hyperkalemic hypertension.
Sharma P et al.
Cell Communication and Signaling : Ccs, 2023
Identification of a novel KLHL3-interacting motif in the C-terminal region of WNK4.
Wang L et al.
Biochemical and Biophysical Research Communications, 2023
The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis.
Lin SC et al.
Biomedicines, 2022
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.
Chen Z et al.
The Biochemical Journal, 2022
WNK4 kinase: from structure to physiology.
Murillo-de-Ozores AR et al.
American Journal of Physiology. Renal Physiology, 2021
The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney.
Anderegg MA et al.
Kidney International, 2021
Investigating specificity of the anti-hypertensive inhibitor WNK463 against With-No-Lysine kinase family isoforms via multiscale simulations.
Jonniya NA et al.
Journal of Biomolecular Structure & Dynamics, 2020
Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics Simulation.
Wang L et al.
Biochemistry, 2019
WNK signalling pathways in blood pressure regulation.
Murthy M et al.
Cellular and Molecular Life Sciences : Cmls, 2017
Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.
Sohara E et al.
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 2016
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.
Maruyama J et al.
Scientific Reports, 2016
Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.
Zhang C et al.
Biochemical and Biophysical Research Communications, 2016
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Bazúa-Valenti S et al.
American Journal of Physiology. Cell Physiology, 2015
Disorders of aldosterone synthesis, secretion, and cellular function.
Root AW
Current Opinion in Pediatrics, 2014
Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.
Schumacher FR et al.
The Biochemical Journal, 2014
Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).
Glover M et al.
Clinical Science (london, England : 1979), 2014
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
Ohta A et al.
The Biochemical Journal, 2013
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
Wakabayashi M et al.
Cell Reports, 2013
Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites.
Na T et al.
American Journal of Physiology. Renal Physiology, 2013
Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
Na T et al.
Biochemical and Biophysical Research Communications, 2012
WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.
Zhou B et al.
American Journal of Physiology. Renal Physiology, 2012
A WNK4 gene variant relates to osteoporosis and not to hypertension in the Portuguese population.
Mendes AI et al.
Molecular Genetics and Metabolism, 2011
Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II.
Zhang C et al.
Nephron. Physiology, 2011
[Study on the association between genetic polymorphism on WNK4 genes and essential hypertension among Kazakhs ethnic population, in Xinjiang].
Cao FF et al.
Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 2010
WNK4 polymorphisms and essential hypertension in the Uyghur population.
Lu M et al.
Clinical and Experimental Hypertension (new York, N.y. : 1993), 2009
A patient with pseudohypoaldosteronism type II caused by a novel mutation in WNK4 gene.
Gong H et al.
Endocrine, 2008
WNK kinases, renal ion transport and hypertension.
San-Cristobal P et al.
American Journal of Nephrology, 2008
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.
Yang SS et al.
Cell Metabolism, 2007
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.
Jiang Y et al.
American Journal of Physiology. Renal Physiology, 2007
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells.
Cai H et al.
Kidney International, 2006
Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.
Peng JB et al.
Kidney International, 2006
Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice.
Yamauchi K et al.
Biochemical and Biophysical Research Communications, 2005
Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells.
Yang SS et al.
Biochemical and Biophysical Research Communications, 2005
Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension.
Gamba G
American Journal of Physiology. Renal Physiology, 2005
[WNK1 and WNK4, new players in salt and water homeostasis].
Hadchouel J et al.
Medecine Sciences : M/s, 2005
Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.
Kamide K et al.
American Journal of Hypertension, 2004