Associated Papers
Familial Hyperkalemic Hypertension.
Cornelius RJ et al.
Comprehensive Physiology, 2024
Expression of the kidney anion exchanger 1 affects WNK4 and SPAK phosphorylation and results in claudin-4 phosphorylation.
Lashhab R et al.
Heliyon, 2023
Insights into the diverse mechanisms and effects of variant CUL3-induced familial hyperkalemic hypertension.
Sharma P et al.
Cell Communication and Signaling : Ccs, 2023
Identification of a novel KLHL3-interacting motif in the C-terminal region of WNK4.
Wang L et al.
Biochemical and Biophysical Research Communications, 2023
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.
Chen Z et al.
The Biochemical Journal, 2022
WNK4 kinase: from structure to physiology.
Murillo-de-Ozores AR et al.
American Journal of Physiology. Renal Physiology, 2021
Investigating specificity of the anti-hypertensive inhibitor WNK463 against With-No-Lysine kinase family isoforms via multiscale simulations.
Jonniya NA et al.
Journal of Biomolecular Structure & Dynamics, 2020
A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4.
Sakoh T et al.
Molecular Genetics & Genomic Medicine, 2019
Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics Simulation.
Wang L et al.
Biochemistry, 2019
WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.
Susa K et al.
Biochemical and Biophysical Research Communications, 2017
WNK signalling pathways in blood pressure regulation.
Murthy M et al.
Cellular and Molecular Life Sciences : Cmls, 2017
Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.
Sohara E et al.
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 2016
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.
Maruyama J et al.
Scientific Reports, 2016
Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.
Zhang C et al.
Biochemical and Biophysical Research Communications, 2016
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Bazúa-Valenti S et al.
American Journal of Physiology. Cell Physiology, 2015
Regulation of blood pressure and renal electrolyte balance by Cullin-RING ligases.
Uchida S
Current Opinion in Nephrology and Hypertension, 2014
Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.
Schumacher FR et al.
The Biochemical Journal, 2014
Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter measurement.
Isobe K et al.
American Journal of Physiology. Renal Physiology, 2013
Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.
Mori Y et al.
Biochemical and Biophysical Research Communications, 2013
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
Ohta A et al.
The Biochemical Journal, 2013
Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites.
Na T et al.
American Journal of Physiology. Renal Physiology, 2013
Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
Na T et al.
Biochemical and Biophysical Research Communications, 2012
Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.
Chiga M et al.
Journal of Cell Science, 2011
A WNK4 gene variant relates to osteoporosis and not to hypertension in the Portuguese population.
Mendes AI et al.
Molecular Genetics and Metabolism, 2011
Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II.
Zhang C et al.
Nephron. Physiology, 2011
Pathophysiological roles of WNK kinases in the kidney.
Uchida S
Pflugers Archiv : European Journal of Physiology, 2010
[Study on the association between genetic polymorphism on WNK4 genes and essential hypertension among Kazakhs ethnic population, in Xinjiang].
Cao FF et al.
Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 2010
WNK4 polymorphisms and essential hypertension in the Uyghur population.
Lu M et al.
Clinical and Experimental Hypertension (new York, N.y. : 1993), 2009
A patient with pseudohypoaldosteronism type II caused by a novel mutation in WNK4 gene.
Gong H et al.
Endocrine, 2008
WNK kinases, renal ion transport and hypertension.
San-Cristobal P et al.
American Journal of Nephrology, 2008
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.
Yang SS et al.
Cell Metabolism, 2007
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.
Jiang Y et al.
American Journal of Physiology. Renal Physiology, 2007
Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice.
Yamauchi K et al.
Biochemical and Biophysical Research Communications, 2005
Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells.
Yang SS et al.
Biochemical and Biophysical Research Communications, 2005
WNK kinases and the control of blood pressure.
Cope G et al.
Pharmacology & Therapeutics, 2005
Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension.
Gamba G
American Journal of Physiology. Renal Physiology, 2005
[WNK1 and WNK4, new players in salt and water homeostasis].
Hadchouel J et al.
Medecine Sciences : M/s, 2005
Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.
Kamide K et al.
American Journal of Hypertension, 2004
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
Yamauchi K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2004