Associated Papers
Identification of a novel KLHL3-interacting motif in the C-terminal region of WNK4.
Wang L et al.
Biochemical and Biophysical Research Communications, 2023
The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis.
Lin SC et al.
Biomedicines, 2022
WNK4 kinase: from structure to physiology.
Murillo-de-Ozores AR et al.
American Journal of Physiology. Renal Physiology, 2021
Investigating specificity of the anti-hypertensive inhibitor WNK463 against With-No-Lysine kinase family isoforms via multiscale simulations.
Jonniya NA et al.
Journal of Biomolecular Structure & Dynamics, 2020
Partially automated whole-genome sequencing reanalysis of previously undiagnosed pediatric patients can efficiently yield new diagnoses.
James KN et al.
Npj Genomic Medicine, 2020
Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters.
Murillo-de-Ozores AR et al.
Frontiers in Physiology, 2020
Assessment of the ExAC data set for the presence of individuals with pathogenic genotypes implicated in severe Mendelian pediatric disorders.
Tarailo-Graovac M et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2017
WNK signalling pathways in blood pressure regulation.
Murthy M et al.
Cellular and Molecular Life Sciences : Cmls, 2017
Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study.
Wang L et al.
Protein Science : a Publication of the Protein Society, 2017
Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.
Sohara E et al.
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 2016
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.
Maruyama J et al.
Scientific Reports, 2016
Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.
Zhang C et al.
Biochemical and Biophysical Research Communications, 2016
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Bazúa-Valenti S et al.
American Journal of Physiology. Cell Physiology, 2015
Disorders of aldosterone synthesis, secretion, and cellular function.
Root AW
Current Opinion in Pediatrics, 2014
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
Wu G et al.
Febs Letters, 2013
WNK4 is an essential effector of anterior formation in FGF signaling.
Shimizu M et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2013
Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites.
Na T et al.
American Journal of Physiology. Renal Physiology, 2013
WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.
Zhou B et al.
American Journal of Physiology. Renal Physiology, 2012
A WNK4 gene variant relates to osteoporosis and not to hypertension in the Portuguese population.
Mendes AI et al.
Molecular Genetics and Metabolism, 2011
Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II.
Zhang C et al.
Nephron. Physiology, 2011
A patient with pseudohypoaldosteronism type II caused by a novel mutation in WNK4 gene.
Gong H et al.
Endocrine, 2008
WNK kinases, renal ion transport and hypertension.
San-Cristobal P et al.
American Journal of Nephrology, 2008
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.
Jiang Y et al.
American Journal of Physiology. Renal Physiology, 2007
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells.
Cai H et al.
Kidney International, 2006
Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.
Peng JB et al.
Kidney International, 2006
[WNK1 and WNK4, new players in salt and water homeostasis].
Hadchouel J et al.
Medecine Sciences : M/s, 2005
Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.
Kamide K et al.
American Journal of Hypertension, 2004