Associated Papers
DNA double-strand break end resection factors and WRN facilitate mitotic DNA synthesis in human cells.
Barwacz SA et al.
Nature Communications, 2025
Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2-RAD51.
Xie H et al.
Nature Chemical Biology, 2025
PLK1 phosphorylates WRN at replication forks.
Wang L et al.
The Journal of Pharmacology and Experimental Therapeutics, 2025
Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure.
Noto A et al.
Nature Communications, 2025
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells.
Lazarchuk P et al.
Aging, 2024
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.
Ceppi I et al.
Nature, 2024
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.
Mackay HL et al.
Nature Communications, 2024
Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome Protein.
Orren DK et al.
International Journal of Molecular Sciences, 2024
PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES.
Noto A et al.
Biorxiv : the Preprint Server for Biology, 2023
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Mengoli V et al.
The Embo Journal, 2023
A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection.
Romero-Zamora D et al.
Scientific Reports, 2023
Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells.
Leung AO et al.
Cell & Bioscience, 2022
WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome.
Tian Y et al.
Nature Communications, 2022
Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer.
Gupta P et al.
Aging Cell, 2022
WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.
Datta A et al.
Nature Communications, 2021
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Newman JA et al.
Life Science Alliance, 2021
Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability.
Marabitti V et al.
Cancers, 2020
RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.
Aiello FA et al.
Nucleic Acids Research, 2019
ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells.
Marabitti V et al.
Nucleic Acids Research, 2019
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM et al.
Nature, 2019
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Lieb S et al.
Elife, 2019
Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins.
Maity J et al.
Dna Repair, 2018
WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1.
Sun L et al.
Nucleic Acids Research, 2017
WRN regulates pathway choice between classical and alternative non-homologous end joining.
Shamanna RA et al.
Nature Communications, 2016
CDK1 phosphorylates WRN at collapsed replication forks.
Palermo V et al.
Nature Communications, 2016
Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.
Pinto C et al.
Elife, 2016
The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.
Grundy GJ et al.
Nature Communications, 2016
The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.
Iannascoli C et al.
Nucleic Acids Research, 2015
The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events.
Edwards DN et al.
Nature Communications, 2015
DNA2 drives processing and restart of reversed replication forks in human cells.
Thangavel S et al.
The Journal of Cell Biology, 2015
Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.
Basile G et al.
Nucleic Acids Research, 2014
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa.
Maddukuri L et al.
Nucleic Acids Research, 2014
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
Edwards DN et al.
Nucleic Acids Research, 2014
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Aggarwal M et al.
Cancer Research, 2013
Functional deficit associated with a missense Werner syndrome mutation.
Tadokoro T et al.
Dna Repair, 2013