Associated Papers
Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.
Yagi T et al.
Journal of Diabetes Investigation, 2026
Prevalence of germline pathogenic variants in cancer predisposition genes in the Japanese population.
Yamaguchi T et al.
Japanese Journal of Clinical Oncology, 2025
The Converging Roles of Nucleases and Helicases in Genome Maintenance and the Aging Process.
Margariti A et al.
Life (basel, Switzerland), 2025
A case of rapid-progressing liver cirrhosis complicated by Werner syndrome.
Miyajima S et al.
Clinical Journal of Gastroenterology, 2025
A Rare Cause of Acute Pancreatitis: Two Siblings With Werner Syndrome.
Sakar K et al.
Jcem Case Reports, 2025
Functional Homologous Recombination (HR) Screening Shows the Majority of BRCA1/2-Mutant Breast and Ovarian Cancer Cell Lines Are HR-Proficient.
Meijer TG et al.
Cancers, 2024
Sex differences in symptom presentation and their impact on diagnostic accuracy in Werner syndrome.
Kaneko H et al.
Geriatrics & Gerontology International, 2024
Werner Syndrome Caused by Homozygous Frameshift Variant c.1578del in WRN.
Druta JP et al.
Acta Medica Lituanic, 2024
Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street.
Balinisteanu I et al.
Biomedicines, 2023
Mutation Analysis of Autosomal-Dominant Polycystic Kidney Disease Patients.
Suzuki Y et al.
Genes, 2023
Splicing-Disrupting Mutations in Inherited Predisposition to Solid Pediatric Cancer.
Alba-Pavón P et al.
Cancers, 2022
Optical coherence tomography findings in three patients with Werner syndrome.
Nagai T et al.
Bmc Ophthalmology, 2022
Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases.
Miller DE et al.
Journal of Medical Genetics, 2022
Werner syndrome presenting as early-onset diabetes: A case report.
Wang X et al.
Journal of Diabetes Investigation, 2022
Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates.
Cameselle-Teijeiro JM et al.
Endocrine Pathology, 2021
WRN Germline Mutation Is the Likely Inherited Etiology of Various Cancer Types in One Iranian Family.
Norouzi M et al.
Frontiers in Oncology, 2021
Evaluation of glucose tolerance and effect of dietary management on increased visceral fat in a patient with Werner syndrome.
Yamamoto R et al.
Endocrine Journal, 2020
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Fang EF et al.
Nature Communications, 2019
Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C.
Matsumoto N et al.
Internal Medicine (tokyo, Japan), 2019
Werner's Syndrome: Understanding the Phenotype of Premature Aging-First Case Described in Colombia.
Rincón A et al.
Case Reports in Genetics, 2019
Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients.
Maezawa Y et al.
Molecular Syndromology, 2018
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.
Waszak SM et al.
The Lancet. Oncology, 2018
Recent Trends in WRN Gene Mutation Patterns in Individuals with Werner Syndrome.
Yamaga M et al.
Journal of the American Geriatrics Society, 2017
WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.
Yokote K et al.
Human Mutation, 2017
Werner syndrome through the lens of tissue and tumour genomics.
Tokita M et al.
Scientific Reports, 2016
WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.
Sadahira Y et al.
Virchows Archiv : an International Journal of Pathology, 2015
Genome-wide discovery of human splicing branchpoints.
Mercer TR et al.
Genome Research, 2015
Endocrine and metabolic abnormalities in a girl with childhood Werner syndrome: case report.
Toda N et al.
Journal of the American Geriatrics Society, 2014
Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.
Shimamoto A et al.
Plos One, 2014
Ethnic-Specific WRN Mutations in South Asian Werner Syndrome Patients: Potential Founder Effect in Patients with Indian or Pakistani Ancestry.
Saha B et al.
Molecular Genetics & Genomic Medicine, 2013
The epidemiology of premature aging and associated comorbidities.
Coppedè F
Clinical Interventions in Aging, 2013
Clinical utility gene card for: Werner syndrome.
Hisama FM et al.
European Journal of Human Genetics : Ejhg, 2012
A case of Werner syndrome without metabolic abnormality: implications for the early pathophysiology.
Takada-Watanabe A et al.
Geriatrics & Gerontology International, 2012
Primary liver tumor associated with Werner syndrome (adult progeria).
Okano H et al.
Hepatology Research : the Official Journal of the Japan Society of Hepatology, 2011
Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Chun SG et al.
Cancer Biology & Therapy, 2010
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations.
Friedrich K et al.
Human Genetics, 2010
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.
Muftuoglu M et al.
Human Genetics, 2008
The spectrum of WRN mutations in Werner syndrome patients.
Huang S et al.
Human Mutation, 2006
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.
Chen L et al.
Aging Cell, 2003
WRN helicase expression in Werner syndrome cell lines.
Moser MJ et al.
Nucleic Acids Research, 2000