Varaico: Literature-Extracted Genetic Variants

Gene:WWP1
Variant:p.K63R
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WWP1

NM_007013.4:p.K63R

Associated Papers

Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.

French ME et al.

The Journal of Biological Chemistry, 2017

Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin.

Lin L et al.

Brain Research, 2016

Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.

Courivaud T et al.

The Journal of Biological Chemistry, 2015

WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts.

Cao X et al.

The Journal of Biological Chemistry, 2011

The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages.

Peschiaroli A et al.

Biochemical and Biophysical Research Communications, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."