Varaico: Literature-Extracted Genetic Variants

Gene:WWP2
Variant:p.R436Q
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WWP2

NM_001270454.2:p.R436Q

Associated Papers

The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function.

Imamura M et al.

In Vitro Cellular & Developmental Biology. Animal, 2024

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."