Associated Papers
Mutations of Key Functional Residues in CRM1/XPO1 Differently Alter Its Intranuclear Localization and the Nuclear Export of Endogenous Cargos.
Omaetxebarria MJ et al.
Biomolecules, 2024
A first-in-class inhibitor of HSP110 to potentiate XPO1-targeted therapy in primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma.
Durand M et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2024
Novel-and Not So Novel-Inhibitors of the Multifunctional CRM1 Protein.
Aumann WK et al.
Oncology Reviews, 2024
Exportin 1-mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma.
Caillot M et al.
Molecular Oncology, 2023
E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1.
Kwanten B et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2023
XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma.
Miloudi H et al.
Cancers, 2020
Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1.
Shaikhqasem A et al.
Journal of Medicinal Chemistry, 2020
Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis.
Taylor J et al.
Cancer Discovery, 2019
Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes.
Neggers JE et al.
Nature Communications, 2018
XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy.
Camus V et al.
Journal of Hematology & Oncology, 2017
A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.
García-Santisteban I et al.
Cellular and Molecular Life Sciences : Cmls, 2016
Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export.
Neggers JE et al.
Oncotarget, 2016
XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.
Kim J et al.
Nature, 2016
Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma.
Jardin F et al.
American Journal of Hematology, 2016
Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing.
Neggers JE et al.
Chemistry & Biology, 2015
Role of the intracellular localization of HIF-prolyl hydroxylases.
Yasumoto K et al.
Biochimica Et Biophysica Acta, 2009
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.
Kau TR et al.
Cancer Cell, 2003