Varaico: Literature-Extracted Genetic Variants

Gene:XRCC1
Variant:p.T519A
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XRCC1

NM_006297.3:p.T519A

Associated Papers

Species variations in XRCC1 recruitment strategies for FHA domain-containing proteins.

London RE

Dna Repair, 2022

XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity.

Horton JK et al.

Dna Repair, 2018

XRCC1-mediated repair of strand breaks independent of PNKP binding.

Horton JK et al.

Dna Repair, 2017

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.

Breslin C et al.

The Journal of Biological Chemistry, 2017

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

Weinfeld M et al.

Trends in Biochemical Sciences, 2011

The FHA domain of PNKP is essential for its recruitment to DNA damage sites and maintenance of genome stability.

Tsukada K et al.

Mutation Research, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."