Varaico: Literature-Extracted Genetic Variants

Gene:XRCC1
Variant:p.R280H
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XRCC1

NM_006297.3:p.R280H

Associated Papers

Genetic polymorphisms in DNA repair gene XRCC1 and the risk of diabetic polyneuropathy.

Hashim NA et al.

Scientific Reports, 2026

Molecular Mechanisms of Preventable Causes of Oral Cancer and Precancer Through Polymorphism in DNA Base Excision Repair Genes in Patients with Tobacco Products Habits.

Sundaram E et al.

Journal of Maxillofacial and Oral Surgery, 2025

XRCC1 Arg399Gln Genetic Variant Increases Colorectal Cancer Susceptibility: A Comprehensive Meta-Analysis.

Kampalli PK et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

A Case-Control Study on Combined Effects of Base Excision Repair and Nucleotide Excision Repair Gene Polymorphisms in Gastrointestinal Cancer Susceptibility.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

The Role of Single Nucleotide Polymorphisms at the Arg399Gln Locus of the XRCC1 Gene in Patients with Non-Small Cell Lung Cancer (NSCLC).

Smolarz B et al.

International Journal of Molecular Sciences, 2025

Association of XRCC1 Gene Polymorphism with an Increased Risk of Hepatocellular Carcinoma in the Peshawar Population.

Hassen RSA et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

Molecular dynamics simulations reveal R399Q mutation disrupts XRCC1-polβ interaction, potentially impairing DNA base excision repair pathway.

Goswami N et al.

Journal of Biomolecular Structure & Dynamics, 2025

XRCC1 Polymorphisms p.Arg194Trp, p.Arg280His, and p.Arg399Gln, Polycyclic Aromatic Hydrocarbons, and Infertility: A Case-Control and In Silico Study.

Sahota JS et al.

Biochemical Genetics, 2025

Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms.

Canchi Sistla H et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2025

Genetic Navigation: A Narrative Review of XRCC1 Polymorphism Impact on Platinum-Based Chemotherapy Outcomes in NSCLC Patients.

Permatasari LI et al.

Cancer Management and Research, 2025

Genetic Polymorphisms of DNA Repair Genes and their Influence on Paclitaxel based Chemotherapy Induced Toxicity Reactions in Breast Cancer Patients.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

Investigating Tobacco's Impact on DNA Repair Genes and Risks in Oral Precancer and Cancer: A Comprehensive Research Study.

Mohammad S et al.

Journal of Maxillofacial and Oral Surgery, 2024

Influence of genetic polymorphisms of Hg metabolism and DNA repair on the frequencies of micronuclei, nucleoplasmic bridges, and nuclear buds in communities living in gold mining areas.

Espitia-Pérez L et al.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2024

Impact of DNA ligase 1 and IIIα interactions with APE1 and polβ on the efficiency of base excision repair pathway at the downstream steps.

Almohdar D et al.

The Journal of Biological Chemistry, 2024

Polymorphisms of DNA Repair Genes in Thyroid Cancer.

Gielecińska A et al.

International Journal of Molecular Sciences, 2024

Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland.

Nurminen R et al.

Scientific Reports, 2024

38773237 (PubMed )
Supplement: 41598_2024_62296_MOESM2_ESM.xlsx › Supplementary_Table_8

NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.

Wang Y et al.

Cell Genomics, 2024

38697125 (PubMed )
Supplement: mmc15.pdf

Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway.

Almohdar D et al.

Journal of Molecular Biology, 2024

Extreme acute radiation-induced toxicity in a patient with polymorphous low-grade adenocarcinoma of the nasopharynx and rare variants in DNA repair genes.

Nowicka Z et al.

Head & Neck, 2024

Gene variants polymorphisms and uterine leiomyoma: an updated review.

Upadhyay S et al.

Frontiers in Genetics, 2024

Genetic polymorphisms and platinum-induced hematological toxicity: a systematic review.

Zheng Y et al.

Frontiers in Pharmacology, 2024

Single Nucleotide Polymorphisms in DNA Repair Genes (XRCC1, XRCC2, XRCC3) and Their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients:A Study from South-Western Maharashtra.

Gudur AK et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2023

Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2023

Association of buccal micronucleus cytome assay (BMNCyt) biomarkers with inorganic element concentration and genetic polymorphisms in welders.

Quintana-Sosa M et al.

Environmental Toxicology and Pharmacology, 2023

Genetic Polymorphisms Involved in Bladder Cancer: A Global Review.

Kourie HR et al.

Oncology Reviews, 2023

Genetic susceptibility of bladder cancer in the Lebanese population.

Kourie HR et al.

Bmc Medical Genomics, 2022

36253817 (PubMed )
Supplement: 12920_2022_1372_MOESM1_ESM.xlsx › sheet_1

Genetic polymorphisms in DNA repair genes and their association with risk of cervical cancer: A systematic review and meta-analysis.

Shao X et al.

The Journal of Obstetrics and Gynaecology Research, 2022

DNA repair gene (XRCC1 and XPD) polymorphism and risk of primary ovarian failure.

Kali Z et al.

European Review for Medical and Pharmacological Sciences, 2022

Impact of Polymorphism in Base Excision Repair and Nucleotide Excision Repair Genes and Risk of Cervical Cancer: A Case-Control Study.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2022

Association study of candidate DNA-repair gene variants and acute graft versus host disease in pediatric patients receiving allogeneic hematopoietic stem-cell transplantation.

Uppugunduri CRS et al.

The Pharmacogenomics Journal, 2022

Introducing a new index for selecting genetic polymorphisms for association studies.

Omidpanah N et al.

Excli Journal, 2022

Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review.

Rajabi-Moghaddam M et al.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2022

A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies.

Zhang XQ et al.

Medicine, 2021

Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis.

Sargazi S et al.

Applied Biochemistry and Biotechnology, 2021

GSTP1 Ile105Val polymorphism among North Indian lung cancer patients treated using monotherapy and poly-pharmacy.

Walia HK et al.

Human & Experimental Toxicology, 2021

Cytokinesis-block micronucleus cytome (CBMN-CYT) assay and its relationship with genetic polymorphisms in welders.

León-Mejía G et al.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2021

Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk.

Ghaderi-Zefrehi H et al.

Dna Repair, 2021

The scaffold protein XRCC1 stabilizes the formation of polβ/gap DNA and ligase IIIα/nick DNA complexes in base excision repair.

Tang Q et al.

The Journal of Biological Chemistry, 2021

A comprehensive meta-analysis and a case-control study give insights into genetic susceptibility of lung cancer and subgroups.

Sengupta D et al.

Scientific Reports, 2021

A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer.

Mandegari M et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2021

Pharmacogenomics and functional imaging to predict irinotecan pharmacokinetics and pharmacodynamics: the predict IR study.

Michael M et al.

Cancer Chemotherapy and Pharmacology, 2021

GA Genotype of the Arg280His Polymorphism on The XRCC1 Gene: Genetic Susceptibility Genotype in Differentiated Thyroid Carcinomas?

Kirnap NG et al.

Balkan Journal of Medical Genetics : Bjmg, 2021

Activated STAT3 Is a Novel Regulator of the XRCC1 Promoter and Selectively Increases XRCC1 Protein Levels in Triple Negative Breast Cancer.

Wright G et al.

International Journal of Molecular Sciences, 2021

DNA Repair Genes and Chronic Myeloid Leukemia: ERCC2 (751), XRCC1 (399), XRCC4-Intron 3, XRCC4 (-1394) Gene Polymorphisms.

Ozdilli K et al.

Mediterranean Journal of Hematology and Infectious Diseases, 2021

Influence of Arg399Gln, Arg280His and Arg194Trp XRCC1 gene polymorphisms of Base Excision Repair pathway on the level of 8-oxo-guanine and risk of head and neck cancer in the Polish population.

Kabzinski J et al.

Cancer Biomarkers : Section a of Disease Markers, 2021

Age- and Gender-Independent Association of XRCC1 Arg399Gln Polymorphism with Chronic Myeloid Leukemia.

Abdalhabib EK et al.

International Journal of General Medicine, 2021

Genetic polymorphisms in XRCC1, OGG1, and XRCC3 DNA repair genes and DNA damage in radiotherapy workers.

Soliman AHM et al.

Environmental Science and Pollution Research International, 2020

DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms.

Rahimian E et al.

Dna Repair, 2020

Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.

Montazeri Z et al.

Gut, 2020

31818908 (PubMed )
Supplement: gutjnl-2019-319313supp002.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."