Varaico: Literature-Extracted Genetic Variants

Gene:XRCC1
Variant:p.R194W
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XRCC1

NM_006297.3:p.R194W

Associated Papers

Role of human papillomavirus (HPV) variants and host genetic susceptibility in cervical carcinogenesis.

Singh A et al.

Archives of Microbiology, 2026

Genetic associations of LXN polymorphisms with toxicities of platinum-based concurrent chemoradiotherapy of nasopharyngeal carcinoma.

Wang Y et al.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 2026

Genetic polymorphisms in DNA repair gene XRCC1 and the risk of diabetic polyneuropathy.

Hashim NA et al.

Scientific Reports, 2026

Targeting ATR-CHK1 and ATM-CHK2 Axes in Pancreatic Cancer-A Comprehensive Review of Literature.

Kciuk M et al.

International Journal of Molecular Sciences, 2026

Structural pharmacogenomics of drug-associated SNPs in oral squamous cell carcinoma.

Sunil P et al.

Frontiers in Genetics, 2026

Impact of pesticide exposure on base excision repair gene polymorphisms in the Haryana population.

Gulia H et al.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 2025

Molecular Mechanisms of Preventable Causes of Oral Cancer and Precancer Through Polymorphism in DNA Base Excision Repair Genes in Patients with Tobacco Products Habits.

Sundaram E et al.

Journal of Maxillofacial and Oral Surgery, 2025

Genetic Polymorphism of MDM2 Gene Associates with Breast Cancer Incidence in the Lower Northern Thailand.

Srikummool M et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

XRCC1 Arg399Gln Genetic Variant Increases Colorectal Cancer Susceptibility: A Comprehensive Meta-Analysis.

Kampalli PK et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

A Case-Control Study on Combined Effects of Base Excision Repair and Nucleotide Excision Repair Gene Polymorphisms in Gastrointestinal Cancer Susceptibility.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by BRCA1 mutation.

Liu J et al.

Science Advances, 2025

40712032 (PubMed )
Supplement: sciadv.adi2370_tables_s8_and_s9.zip › adi2370_table_s9.xlsx › BRCA1-mutant_corrected_iPSC

Potential risk genotypes associated with symptoms of pesticide poisoning based on polymorphisms in the XRCC1 (rs25487 and rs1799782), SOD2 (rs4880), PON1 (rs662) and GSTP1 (rs1695) genes, in farmers in the Cienega region.

Flores Gutiérrez CA et al.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, 2025

The Role of Single Nucleotide Polymorphisms at the Arg399Gln Locus of the XRCC1 Gene in Patients with Non-Small Cell Lung Cancer (NSCLC).

Smolarz B et al.

International Journal of Molecular Sciences, 2025

Association of XRCC1 Gene Polymorphism with an Increased Risk of Hepatocellular Carcinoma in the Peshawar Population.

Hassen RSA et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

Molecular dynamics simulations reveal R399Q mutation disrupts XRCC1-polβ interaction, potentially impairing DNA base excision repair pathway.

Goswami N et al.

Journal of Biomolecular Structure & Dynamics, 2025

APEX1 Polymorphisms Affect Acute Myeloid Leukemia Risk, and Its Expression Is Involved in Cell Proliferation and Differentiation.

Gotoh N et al.

International Journal of Laboratory Hematology, 2025

Defective DNA repair: a putative nexus linking immunological diseases, neurodegenerative disorders, and cancer.

Andarawi S et al.

Mutagenesis, 2025

Association of XRCC1 (rs1799782) and XPD (rs13181) gene polymorphisms with renal failure risk in a sample of Iraqi population: a case-control study.

Abo-Ghneim FDF et al.

Molecular Biology Reports, 2025

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

39991480 (PubMed )
Supplement: mmc5.xlsx › Sheet1

XRCC1 Polymorphisms p.Arg194Trp, p.Arg280His, and p.Arg399Gln, Polycyclic Aromatic Hydrocarbons, and Infertility: A Case-Control and In Silico Study.

Sahota JS et al.

Biochemical Genetics, 2025

Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms.

Canchi Sistla H et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2025

Genetic signatures of ERCC1 and ERCC2 expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy.

Caliman E et al.

Oncology Research, 2025

Genetic Navigation: A Narrative Review of XRCC1 Polymorphism Impact on Platinum-Based Chemotherapy Outcomes in NSCLC Patients.

Permatasari LI et al.

Cancer Management and Research, 2025

Genetic Polymorphisms of DNA Repair Genes and their Influence on Paclitaxel based Chemotherapy Induced Toxicity Reactions in Breast Cancer Patients.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

Multi-index comprehensive evaluation of the efficacy and response mechanism of immunotherapy in non-small cell lung cancer.

Fan J et al.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2024

Unravelling the molecular tapestry of pterygium: insights into genes for diagnostic and therapeutic innovations.

Gupta M et al.

Eye (london, England), 2024

Prognostic and Predictive Markers for Early Stage Triple-Negative Breast Cancer Treated With Platinum-Based Neoadjuvant Chemotherapy.

Zhao Z et al.

Cancer Medicine, 2024

XRCC1 and XPD polymorphisms: clinical outcomes and risk of prostate cancer in Bangladeshi population.

Ahmed N et al.

Molecular Biology Reports, 2024

Investigating Tobacco's Impact on DNA Repair Genes and Risks in Oral Precancer and Cancer: A Comprehensive Research Study.

Mohammad S et al.

Journal of Maxillofacial and Oral Surgery, 2024

Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis.

Aguiar BRL et al.

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [et Al], 2024

Influence of genetic polymorphisms of Hg metabolism and DNA repair on the frequencies of micronuclei, nucleoplasmic bridges, and nuclear buds in communities living in gold mining areas.

Espitia-Pérez L et al.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2024

Impact of DNA ligase 1 and IIIα interactions with APE1 and polβ on the efficiency of base excision repair pathway at the downstream steps.

Almohdar D et al.

The Journal of Biological Chemistry, 2024

Interactive Association of XRCC1, XRCC2, XRCC3, and TP53 Gene Polymorphisms With Gastrointestinal Cancer Risk: Insights From a Hospital-Based Case-Control Study.

Datkhile KD et al.

Cureus, 2024

Polymorphisms of DNA Repair Genes in Thyroid Cancer.

Gielecińska A et al.

International Journal of Molecular Sciences, 2024

Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland.

Nurminen R et al.

Scientific Reports, 2024

38773237 (PubMed )
Supplement: 41598_2024_62296_MOESM2_ESM.xlsx › Supplementary_Table_8

Genetic markers of cardiac autonomic neuropathy in the Kazakh population.

Bekenova N et al.

Bmc Cardiovascular Disorders, 2024

ACE Phenotyping in Human Blood and Tissues: Revelation of ACE Outliers and Sex Differences in ACE Sialylation.

Enyedi EE et al.

Biomedicines, 2024

38790902 (PubMed )
Supplement: biomedicines-12-00940-s001.zip › biomedicines-2930173-supplementary.pdf

Chromosomal Damage, Chromosome Instability, and Polymorphisms in GSTP1 and XRCC1 as Biomarkers of Effect and Susceptibility in Farmers Exposed to Pesticides.

Aldana-Salazar F et al.

International Journal of Molecular Sciences, 2024

Single Nucleotide Polymorphisms as Biomarker Predictors of Oral Mucositis Severity in Head and Neck Cancer Patients Submitted to Combined Radiation Therapy and Chemotherapy: A Systematic Review.

Cavalieri R et al.

Cancers, 2024

Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway.

Almohdar D et al.

Journal of Molecular Biology, 2024

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines.

Lozinski M et al.

Oncotarget, 2024

38227740 (PubMed )
Supplement: oncotarget-15-28551-s001.pdf

Genetic polymorphisms as potential pharmacogenetic biomarkers for platinum-based chemotherapy in non-small cell lung cancer.

Sito H et al.

Molecular Biology Reports, 2024

XRCC1: a potential prognostic and immunological biomarker in LGG based on systematic pan-cancer analysis.

Wang G et al.

Aging, 2024

Genetic polymorphisms and platinum-induced hematological toxicity: a systematic review.

Zheng Y et al.

Frontiers in Pharmacology, 2024

Dissecting the genetic variations associated with response to first-line chemotherapy in patients with small cell lung cancer: a retrospective cohort study.

Zhang Y et al.

Journal of Thoracic Disease, 2023

The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity.

Alves AA et al.

Biochemical Genetics, 2023

Association between XRCC1 Arg399Gln polymorphism with prognosis of head and neck squamous cell carcinomas: A meta-analysis.

Najafi-Ghobadi K et al.

Heliyon, 2023

X-ray cross-complementing family: the bridge linking DNA damage repair and cancer.

Liu Q et al.

Journal of Translational Medicine, 2023

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