Varaico: Literature-Extracted Genetic Variants

Gene:XRCC2
Variant:p.R188H
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XRCC2

NM_005431.2:p.R188H

Associated Papers

Integrated case-control and in silico analysis of DNA double-strand break repair gene variants (RAD51, XRCC2, XRCC3, XRCC4, and LIG4) for ovarian cancer susceptibility.

Sistla HC et al.

Gene, 2026

A Case-Control Study on Combined Effects of Base Excision Repair and Nucleotide Excision Repair Gene Polymorphisms in Gastrointestinal Cancer Susceptibility.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

Single-nucleotide polymorphisms in DNA repair genes ERCC, XRCC, and MGMT and implications in glioblastoma: a pathway analysis and structural dynamics study.

Afshar Y et al.

Journal of Biomolecular Structure & Dynamics, 2025

Integrative Computational Analysis of Common EXO5 Haplotypes: Impact on Protein Dynamics, Genome Stability, and Cancer Progression.

Mazza F et al.

Journal of Chemical Information and Modeling, 2025

40115981 (PubMed )
Supplement: ci5c00067_si_002.xlsx › scored_ALL_haplotypes_1MAF_cano

Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms.

Canchi Sistla H et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2025

Genetic Polymorphisms of DNA Repair Genes and their Influence on Paclitaxel based Chemotherapy Induced Toxicity Reactions in Breast Cancer Patients.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

Association of XRCC2 with breast cancer, a multi-omics analysis at genomic, transcriptomic, and epigenomic level.

Gilani N et al.

Cellular and Molecular Biology (noisy-le-grand, France), 2024

Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families reveals complex genetic architecture and phenocopies.

Plowman JN et al.

Hgg Advances, 2024

38734904 (PubMed )
Supplement: mmc2.xlsx › Table_S5

Interactive Association of XRCC1, XRCC2, XRCC3, and TP53 Gene Polymorphisms With Gastrointestinal Cancer Risk: Insights From a Hospital-Based Case-Control Study.

Datkhile KD et al.

Cureus, 2024

Polymorphisms of DNA Repair Genes in Thyroid Cancer.

Gielecińska A et al.

International Journal of Molecular Sciences, 2024

Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland.

Nurminen R et al.

Scientific Reports, 2024

38773237 (PubMed )
Supplement: 41598_2024_62296_MOESM2_ESM.xlsx › Supplementary_Table_8

Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort.

Vanni I et al.

Journal of Translational Medicine, 2024

38750555 (PubMed )
Supplement: 12967_2024_5227_MOESM14_ESM.xlsx › S14

Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma.

Tian W et al.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 2024

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines.

Lozinski M et al.

Oncotarget, 2024

38227740 (PubMed )
Supplement: oncotarget-15-28551-s001.pdf

Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis.

Dastgheib SA et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

Clinico-genomic findings, molecular docking, and mutational spectrum in an understudied population with breast cancer patients from KP, Pakistan.

Ahmad H et al.

Frontiers in Genetics, 2024

X-ray cross-complementing family: the bridge linking DNA damage repair and cancer.

Liu Q et al.

Journal of Translational Medicine, 2023

Single Nucleotide Polymorphisms in DNA Repair Genes (XRCC1, XRCC2, XRCC3) and Their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients:A Study from South-Western Maharashtra.

Gudur AK et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2023

Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2023

The interplay between XPG-Asp1104His polymorphism and reproductive risk factors elevates risk of breast cancer in Tanzanian women: A multiple interaction analysis.

Adolf IC et al.

Cancer Medicine, 2023

Relationship between polymorphisms in homologous recombination repair genes RAD51 G172T、XRCC2 & XRCC3 and risk of breast cancer: A meta-analysis.

Yu J et al.

Frontiers in Oncology, 2023

Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer.

Keskin Karakoyun H et al.

Frontiers in Genetics, 2023

36896237 (PubMed )
Supplement: Table1.xlsx › clinvar_breastcancer_allvariant

Genetic susceptibility of bladder cancer in the Lebanese population.

Kourie HR et al.

Bmc Medical Genomics, 2022

36253817 (PubMed )
Supplement: 12920_2022_1372_MOESM1_ESM.xlsx › sheet_1

Genetic polymorphisms in DNA repair genes and their association with risk of cervical cancer: A systematic review and meta-analysis.

Shao X et al.

The Journal of Obstetrics and Gynaecology Research, 2022

A review on the genetic polymorphisms and susceptibility of cancer patients in Bangladesh.

Babu G et al.

Molecular Biology Reports, 2022

The Fanconi anemia pathway and Breast Cancer: A comprehensive review of clinical data.

Gianni P et al.

Clinical Breast Cancer, 2022

Haplotypes of single cancer driver genes and their local ancestry in a highly admixed long-lived population of Northeast Brazil.

Galisa SLG et al.

Genetics and Molecular Biology, 2022

Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk.

Ghaderi-Zefrehi H et al.

Dna Repair, 2021

XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis.

Wang Z et al.

The Journal of International Medical Research, 2021

Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.

Toh M et al.

The Oncologist, 2021

Association of RAD51 and XRCC2 Gene Polymorphisms with Cervical Cancer Risk in the Bangladeshi Women.

Ivy SC et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2021

A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer.

Mandegari M et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2021

Recent advances of automated methods for searching and extracting genomic variant information from biomedical literature.

Lee K et al.

Briefings in Bioinformatics, 2021

Association between RAD51, XRCC2 and XRCC3 gene polymorphisms and risk of ovarian cancer: a case control and an in silico study.

Gowtham Kumar G et al.

Molecular Biology Reports, 2021

Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.

Al Hamad M et al.

Applied Immunohistochemistry & Molecular Morphology : Aimm, 2021

Genetic variants and risk of thyroid cancer among Iranian patients.

Jamshidi M et al.

Hormone Molecular Biology and Clinical Investigation, 2021

BRCA2 3'-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p.

Guo N et al.

Pharmacogenomics and Personalized Medicine, 2021

Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes.

Al-Shaheri FN et al.

Experimental and Molecular Pathology, 2020

Role of Rad51 and DNA repair in cancer: A molecular perspective.

Laurini E et al.

Pharmacology & Therapeutics, 2020

Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review.

Tavares CB et al.

Cancer Investigation, 2020

Genetic Variants Detected Using Cell-Free DNA from Blood and Tumor Samples in Patients with Inflammatory Breast Cancer.

Winn JS et al.

International Journal of Molecular Sciences, 2020

32075053 (PubMed )
Supplement: ijms-21-01290-s001.zip › ijms-703397_SI › Supplementary_Table_3.xlsx › Supplementary_Table_2_final

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk.

Kaur J et al.

Clinical and Experimental Gastroenterology, 2020

Analysis of the association between the XRCC2 rs3218536 polymorphism and ovarian cancer risk.

Yuan C et al.

Archives of Medical Science : Ams, 2020

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."