Varaico: Literature-Extracted Genetic Variants

Gene:XRCC3
Variant:p.T241M
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XRCC3

NM_005432.4:p.T241M

Associated Papers

Integrated case-control and in silico analysis of DNA double-strand break repair gene variants (RAD51, XRCC2, XRCC3, XRCC4, and LIG4) for ovarian cancer susceptibility.

Sistla HC et al.

Gene, 2026

The effect of inflammatory factors on unstable angina risk, from the gene level.

Lou J et al.

Scientific Reports, 2026

LINC-PINT expression and rs1059698 polymorphism associate with chemoradiotherapy efficacy in Chinese nasopharyngeal carcinoma patients.

Ma S et al.

Bmc Cancer, 2025

Polymorphisms in DNA repair related genes as risk factors for lung cancer in Cuban population: a case control study.

Reyes-Reyes E et al.

Bmc Cancer, 2025

Integration of germline pharmacogenomic burden to predict fluoropyrimidine-related toxicity - A secondary analysis of the PREPARE trial.

De Mattia E et al.

Oncogene, 2025

Mapping cryptic phosphorylation sites in the human proteome.

Gasparotto D et al.

The Embo Journal, 2025

41044218 (PubMed )
Supplement: 44318_2025_567_MOESM5_ESM.xlsx › Table

A comprehensive compilation of data on the association between XRCC3 polymorphisms and thyroid cancer susceptibility.

Khosravi-Mashzi M et al.

Bmc Endocrine Disorders, 2025

Expression analysis of C-FOS and XRCC3 Thr241Met polymorphism in gastric cancer.

Nizar Jawad Z

Cellular and Molecular Biology (noisy-le-grand, France), 2025

A Case-Control Study on Combined Effects of Base Excision Repair and Nucleotide Excision Repair Gene Polymorphisms in Gastrointestinal Cancer Susceptibility.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

Single-nucleotide polymorphisms in DNA repair genes ERCC, XRCC, and MGMT and implications in glioblastoma: a pathway analysis and structural dynamics study.

Afshar Y et al.

Journal of Biomolecular Structure & Dynamics, 2025

Pan-Cancer Exome-wide analysis of germline mutational patterns and pathways.

Alnaqbi H et al.

Scientific Reports, 2025

40594066 (PubMed )
Supplement: 41598_2025_5296_MOESM2_ESM.xlsx › Supplementary_Table_1

The Impact of Genetic Polymorphisms for Detecting Genotoxicity in Workers Occupationally Exposed to Metals: A Systematic Review.

Pinto TG et al.

Journal of Applied Toxicology : Jat, 2025

Biomarker Potential of DNA Repair Genes XRCC1, XRCC3 and RAD51 Polymorphisms in Ovarian Cancer Patients.

A Y et al.

Cancer Investigation, 2025

Integrative Computational Analysis of Common EXO5 Haplotypes: Impact on Protein Dynamics, Genome Stability, and Cancer Progression.

Mazza F et al.

Journal of Chemical Information and Modeling, 2025

40115981 (PubMed )
Supplement: ci5c00067_si_002.xlsx › scored_ALL_haplotypes_1MAF_cano

Molecular dynamics simulations reveal R399Q mutation disrupts XRCC1-polβ interaction, potentially impairing DNA base excision repair pathway.

Goswami N et al.

Journal of Biomolecular Structure & Dynamics, 2025

Effect of Repair Gene Polymorphism on the Risk of Malignant Neoplasm Development after Chronic Radiation Exposure.

Blinova EA et al.

Doklady. Biochemistry and Biophysics, 2025

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors.

Pacaud R et al.

Breast Cancer Research : Bcr, 2025

39819384 (PubMed )
Supplement: 13058_2024_1954_MOESM5_ESM.xlsx › Sheet1

Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms.

Canchi Sistla H et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2025

Pharmacogenomics and genetic ancestry in Colombia: a study on all variant drug annotations of PharmGKB.

Acosta-Monterrosa AA et al.

Frontiers in Pharmacology, 2025

40949159 (PubMed )
Supplement: Table1.xlsx › Studies

Genetic variants of the XRCC3 DNA repair gene: risk implications in breast cancer among Iraqi patients.

Al-Khalidi ZS et al.

Przeglad Menopauzalny = Menopause Review, 2024

Association Between Polymorphisms in DNA Repair Genes and Glioma Susceptibility: A Meta-Analysis of Four Single Nucleotide Polymorphisms (rs3212986, rs13181, rs25487, and rs861539).

Fotakopoulos G et al.

Cureus, 2024

Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis.

Aguiar BRL et al.

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [et Al], 2024

Influence of genetic polymorphisms of Hg metabolism and DNA repair on the frequencies of micronuclei, nucleoplasmic bridges, and nuclear buds in communities living in gold mining areas.

Espitia-Pérez L et al.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2024

Quantitative assessment of the associations between DNA repair gene XRCC3 Thr241Met polymorphism and pancreatic cancer.

Wu W et al.

World Journal of Surgical Oncology, 2024

Interactive Association of XRCC1, XRCC2, XRCC3, and TP53 Gene Polymorphisms With Gastrointestinal Cancer Risk: Insights From a Hospital-Based Case-Control Study.

Datkhile KD et al.

Cureus, 2024

Single Nucleotide Polymorphisms as Biomarker Predictors of Oral Mucositis Severity in Head and Neck Cancer Patients Submitted to Combined Radiation Therapy and Chemotherapy: A Systematic Review.

Cavalieri R et al.

Cancers, 2024

Extreme acute radiation-induced toxicity in a patient with polymorphous low-grade adenocarcinoma of the nasopharynx and rare variants in DNA repair genes.

Nowicka Z et al.

Head & Neck, 2024

Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis.

Dastgheib SA et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

Genetic polymorphisms and platinum-induced hematological toxicity: a systematic review.

Zheng Y et al.

Frontiers in Pharmacology, 2024

Quantitative assessment of the association between TNF-α gene polymorphisms and angina risk.

Xu S et al.

American Journal of Translational Research, 2024

Role of Single-Nucleotide Polymorphisms in Genes Implicated in Capecitabine Pharmacodynamics on the Effectiveness of Adjuvant Therapy in Colorectal Cancer.

Cura Y et al.

International Journal of Molecular Sciences, 2023

Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer.

Burdett NL et al.

Scientific Reports, 2023

Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis.

Tan IL et al.

Cell Reports, 2023

37917583 (PubMed )
Supplement: NIHMS1948186-supplement-2.xlsx › All-Pat-ClinVar_Coding

DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients.

Butkiewicz D et al.

Cancers, 2023

37894339 (PubMed )
Supplement: cancers-15-04972-s001.zip › cancers-2645185-supplementary.pdf

X-ray cross-complementing family: the bridge linking DNA damage repair and cancer.

Liu Q et al.

Journal of Translational Medicine, 2023

Single Nucleotide Polymorphisms in DNA Repair Genes (XRCC1, XRCC2, XRCC3) and Their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients:A Study from South-Western Maharashtra.

Gudur AK et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2023

Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study.

Datkhile KD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2023

Association of RAD51, XRCC1, XRCC2, and XRCC3 Polymorphisms with Risk of Breast Cancer.

Gupta P et al.

Genetic Testing and Molecular Biomarkers, 2023

Systematic evaluation of the association between a missense variant in XRCC3 gene splicing site and the pathogenesis of ovarian cancer.

Liang Q et al.

Bioscience Reports, 2023

Strong Cumulative Evidence of Associations of 6 Single Nucleotide Polymorphisms with Ovarian Cancer Risk: An Umbrella Review.

Huo YJ et al.

Journal of Clinical Medicine, 2023

36902812 (PubMed )
Supplement: jcm-12-02025-s001.zip › jcm-2179460-supplementary › Supplementary_File_S2.pdf

Germline genetic variants are associated with development of insulin-dependent diabetes in cancer patients treated with immune checkpoint inhibitors.

Caulfield JI et al.

Journal for Immunotherapy of Cancer, 2023

Neural Tube Defects and Folate Deficiency: Is DNA Repair Defective?

Wang X et al.

International Journal of Molecular Sciences, 2023

The interplay between XPG-Asp1104His polymorphism and reproductive risk factors elevates risk of breast cancer in Tanzanian women: A multiple interaction analysis.

Adolf IC et al.

Cancer Medicine, 2023

Association of buccal micronucleus cytome assay (BMNCyt) biomarkers with inorganic element concentration and genetic polymorphisms in welders.

Quintana-Sosa M et al.

Environmental Toxicology and Pharmacology, 2023

Relationship between polymorphisms in homologous recombination repair genes RAD51 G172T、XRCC2 & XRCC3 and risk of breast cancer: A meta-analysis.

Yu J et al.

Frontiers in Oncology, 2023

Association between single nucleotide polymorphisms in DNA repair genes and the efficacy of radiotherapy in nasopharyngeal carcinoma patients.

Benzeid R et al.

Contemporary Oncology (poznan, Poland), 2023

Current perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction.

Gandhi M et al.

Translational Oncology, 2022

Genetic susceptibility of bladder cancer in the Lebanese population.

Kourie HR et al.

Bmc Medical Genomics, 2022

36253817 (PubMed )
Supplement: 12920_2022_1372_MOESM1_ESM.xlsx › sheet_1

NBN, RAD51 and XRCC3 Polymorphisms as Potential Predictive Biomarkers of Adjuvant Radiotherapy Toxicity in Early HER2-Positive Breast Cancer.

Goričar K et al.

Cancers, 2022

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."