Associated Papers
Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.
Aceytuno RD et al.
Nucleic Acids Research, 2017
An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.
Hammel M et al.
The Journal of Biological Chemistry, 2016
Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.
Weinfeld M et al.
Trends in Biochemical Sciences, 2011
Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.
Mani RS et al.
The Journal of Biological Chemistry, 2010
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.
Macrae CJ et al.
Dna Repair, 2008
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.
Koch CA et al.
The Embo Journal, 2004
The FHA domain of PNKP is essential for its recruitment to DNA damage sites and maintenance of genome stability.
Tsukada K et al.
Mutation Research, 0
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