Varaico: Literature-Extracted Genetic Variants

Gene:YOD1
Variant:p.C160S
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YOD1

NM_018566.4:p.C160S

Associated Papers

miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia.

Pei HZ et al.

Cell Death Discovery, 2023

Deubiquitinating enzyme YOD1 deubiquitinates and destabilizes α-synuclein.

Park SS et al.

Biochemical and Biophysical Research Communications, 2023

Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.

Chua NK et al.

The Biochemical Journal, 2019

BiP/GRP78 Mediates ERAD Targeting of Proteins Produced by Membrane-Bound Ribosomes Stalled at the STOP-Codon.

Cesaratto F et al.

Journal of Molecular Biology, 2019

YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity.

Tanji K et al.

Neurobiology of Disease, 2018

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB.

Schimmack G et al.

Elife, 2017

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.

Papadopoulos C et al.

The Embo Journal, 2017

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.

Chen CY et al.

The Embo Journal, 2014

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation.

Locke M et al.

The Biochemical Journal, 2014

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.

Ernst R et al.

Molecular Cell, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."