Associated Papers
Kazachstania pintolopesii triggers an immune-endothelial-fibroblast cascade and drives inflammatory arthritis and tissue fibrosis in genetically susceptible hosts.
Zhang H et al.
Frontiers in Cellular and Infection Microbiology, 2025
The potential of PTPN22 as a therapeutic target for rheumatoid arthritis.
Carmona FD et al.
Expert Opinion on Therapeutic Targets, 2018
Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis.
Lau MC et al.
Annals of the Rheumatic Diseases, 2017
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Sood S et al.
Journal of Immunology (baltimore, Md. : 1950), 2016
The SKG Mutation in ZAP-70 also Confers Arthritis Susceptibility in C57 Black Mouse Strains.
Guerard S et al.
Scandinavian Journal of Immunology, 2016
Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.
Siggs OM et al.
Journal of Immunology (baltimore, Md. : 1950), 2015
Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: family based association study.
Ferjeni Z et al.
Immunology Letters, 2015
Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.
Notarangelo LD
Current Opinion in Immunology, 2014
T cell receptor-associated protein tyrosine kinases: the dynamics of tolerance regulation by phosphorylation and its role in systemic lupus erythematosus.
Barrera-Vargas A et al.
Human Immunology, 2014
A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.
Siggs OM et al.
Immunology, 2014
Contribution of PTPN22, CD28, CTLA-4 and ZAP-70 variants to the risk of type 1 diabetes in Tunisians.
Zouidi F et al.
Gene, 2014
Association of ZAP70 and PTPN6, but Not BANK1 or CLEC2D, with inflammatory bowel disease in the Tunisian population.
Bouzid D et al.
Genetic Testing and Molecular Biomarkers, 2013
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.
Hsu LY et al.
The Journal of Experimental Medicine, 2009
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
Siggs OM et al.
Immunity, 2007
Bruton's tyrosine kinase is essential for human B cell tolerance.
Ng YS et al.
The Journal of Experimental Medicine, 2004