Associated Papers
Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy.
Kent A et al.
Frontiers in Immunology, 2021
Selective defect in antigen-induced TCR internalization at the immune synapse of CD8 T cells bearing the ZAP-70(Y292F) mutation.
Davanture S et al.
Journal of Immunology (baltimore, Md. : 1950), 2005
Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein.
Goda S et al.
Journal of Immunology (baltimore, Md. : 1950), 2004
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.
Thien CB et al.
The Journal of Experimental Medicine, 2003
The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system.
Rao N et al.
Journal of Leukocyte Biology, 2002
Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.
Di Bartolo V et al.
European Journal of Immunology, 2002
The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.
Rao N et al.
The Embo Journal, 2001
T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.
Magnan A et al.
The Journal of Experimental Medicine, 2001
Molecular controls of antigen receptor clustering and autoimmunity.
Krawczyk C et al.
Trends in Cell Biology, 2001
The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells.
Rao N et al.
Journal of Immunology (baltimore, Md. : 1950), 2000
The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase.
Ota S et al.
The Journal of Biological Chemistry, 2000
Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.
Magistrelli G et al.
European Journal of Biochemistry, 1999
The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.
van Leeuwen JE et al.
Molecular and Cellular Biology, 1999
Structural requirements of Syk kinase for Fcgamma receptor-mediated phagocytosis.
Hunter S et al.
Experimental Hematology, 1999
A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.
Zhang Z et al.
Current Biology : Cb, 1999
The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
Lupher ML et al.
The Journal of Biological Chemistry, 1997