Varaico: Literature-Extracted Genetic Variants

Gene:ZAP70
Variant:p.Y315F
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ZAP70

NM_001079.4:p.Y315F

Associated Papers

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.

Sadras T et al.

Molecular Cell, 2021

Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy.

Kent A et al.

Frontiers in Immunology, 2021

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.

Hsu LY et al.

The Journal of Experimental Medicine, 2009

Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein.

Goda S et al.

Journal of Immunology (baltimore, Md. : 1950), 2004

Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.

Di Bartolo V et al.

European Journal of Immunology, 2002

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.

Magnan A et al.

The Journal of Experimental Medicine, 2001

Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.

Magistrelli G et al.

European Journal of Biochemistry, 1999

The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction.

Wu J et al.

The Journal of Experimental Medicine, 1997

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."