Associated Papers
Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.
Reeve MP et al.
Nature Genetics, 2026
Mechanistic insights into the allosteric inactivation mechanism of ZAP-70 induced by the hot spot W165C mutation.
Hu MT et al.
Journal of Biomolecular Structure & Dynamics, 2024
Autoimmune hypothyroidism GWAS reveals independent autoimmune and thyroid-specific contributions and an inverse relation with cancer risk.
Reeve M et al.
Research Square, 2024
Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and disease.
Umerenkov D et al.
Life Science Alliance, 2023
37164635 (PubMed )
Supplement: LSA-2023-01962_TableS6.xlsx › Experimental_by_OMIM
Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain.
Mongellaz C et al.
Frontiers in Immunology, 2023
Are transient protein-protein interactions more dispensable?
Ghadie MA et al.
Plos Computational Biology, 2022
35404956 (PubMed )
Supplement: pcbi.1010013.s002.xlsx › _D__Lit-SI_disMut_edgotypes
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.
Shen L et al.
Science Signaling, 2021
Mutation Edgotype Drives Fitness Effect in Human.
Ghadie M et al.
Frontiers in Bioinformatics, 2021
36303776 (PubMed )
Supplement: Table2.XLSX › _D__Lit-SI_pathMt_edgotype
Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review.
Sharifinejad N et al.
Frontiers in Immunology, 2020
Estimating dispensable content in the human interactome.
Ghadie M et al.
Nature Communications, 2019
31324802 (PubMed )
Supplement: 41467_2019_11180_MOESM6_ESM.xlsx › _D__IntAct-SI_disease_mut
Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency.
Gavino C et al.
The Journal of Allergy and Clinical Immunology, 2017
Novel Mutation of ZAP-70-related Combined Immunodeficiency: First Case from the National Iranian Registry and Review of the Literature.
Shirkani A et al.
Immunological Investigations, 2017
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
Chan AY et al.
The Journal of Experimental Medicine, 2016
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