Associated Papers
Naringenin and SMER28 target lysosomal reformation and rescue SPG11 and SPG15 hereditary spastic paraplegia phenotypes.
Vantaggiato C et al.
Pharmacological Research, 2025
Neurodevelopmental Implications Underpinning Hereditary Spastic Paraplegia.
Zhi Y et al.
Cns Neuroscience & Therapeutics, 2025
39932116 (PubMed )
Supplement: CNS-31-e70260-s001.xlsx › SPG15
Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia.
Vantaggiato C et al.
Brain : a Journal of Neurology, 2023
Case report: Hereditary spastic paraplegia with a novel homozygous mutation in ZFYVE26.
Lai ZH et al.
Frontiers in Neurology, 2023
37681008 (PubMed )
Supplement: Data_Sheet_1.xlsx › Sheet1
ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis.
Vantaggiato C et al.
Autophagy, 2019
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.
Chang J et al.
The Journal of Clinical Investigation, 2014
Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15.
Vantaggiato C et al.
Brain : a Journal of Neurology, 2013
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