Varaico: Literature-Extracted Genetic Variants

Gene:ZNRD2
Variant:p.C53S
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ZNRD2

NM_006396.3:p.C53S

Associated Papers

A cancer-associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss-of-function.

Bencivenga D et al.

Molecular Oncology, 2021

PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer.

Costa C et al.

Cancer Discovery, 2020

Modification of p27 with O-linked N-acetylglucosamine regulates cell proliferation in hepatocellular carcinoma.

Qiu H et al.

Molecular Carcinogenesis, 2017

Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner.

Armenia J et al.

Oncotarget, 2014

24727437 (PubMed )
Supplement: oncotarget-05-1185-s002.pdf

Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.

Mallampalli RK et al.

Cellular Signalling, 2013

Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27.

Yan Y et al.

Cell Cycle (georgetown, Tex.), 2011

Mutant p27(Kip1) and its potential effect as hepatocellular gene therapy.

Lu M et al.

Archives of Medical Research, 2008

Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway.

Schepers H et al.

Experimental Hematology, 2005

14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).

Sekimoto T et al.

The Embo Journal, 2004

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.

Shin I et al.

Nature Medicine, 2002

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."