Varaico: Literature-Extracted Genetic Variants

AFF4

147 papers

RefSeq Summary

The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromo...

Pfam Domains

AF-4aa 2–479UCSCAF-4 proto-oncoprotein N-terminal region

AF4_intaa 714–728UCSCAF4 interaction motif

AFF4_CHDaa 897–1162UCSCAFF4, C-terminal homology domain

Gene Aliases

HGNC Name

ALF transcription elongation factor 4

HGNC Alias Symbols

AF5Q31; MCEF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014423.4

p.V1097D

c.3290T>A

Surrounding Variants

2 papers

NM_014423.4

p.V1097A

c.3290T>C

1 paper

NM_014423.4

p.Y1096F

c.3287A>T

1 paper

NM_014423.4

p.Y1096D

c.3286T>G

1 paper

NM_014423.4

p.Y1096H

c.3286T>C

1 paper

NM_014423.4

p.T1100A

c.3298A>G

1 paper

NM_014423.4

p.A1093V

c.3278C>T

1 paper

NM_014423.4

p.I1089_M1092del4

c.3265_3275del12

1 paper

NM_014423.4

p.M1092I

c.3276G>T

1 paper

NM_014423.4

p.M1092I

c.3276G>C

1 paper

NM_014423.4

p.M1092I

c.3276G>A

1 paper

NM_014423.4

p.H1090D

c.3268C>G

3 papers

NM_014423.4

p.T1107A

c.3319A>G