Varaico: Literature-Extracted Genetic Variants

Gene:AFP
Variant:p.I284F

AFP

574 papers

RefSeq Summary

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma an...

Pfam Domains

Serum_albuminaa 30–202UCSCSerum albumin family
Serum_albuminaa 222–394UCSCSerum albumin family
Serum_albuminaa 414–592UCSCSerum albumin family

Gene Aliases

HGNC Name

alpha fetoprotein

HGNC Previous Symbol

HPAFP

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001134.3
p.I284F
c.850A>T
Surrounding Variants
1 paper
NM_001134.3
p.I284V
c.850A>G
4 papers
NM_001134.3
p.I284_M285delFs
c.851_854del4
1 paper
NM_001134.3
p.I284_M285delFs
c.852_855del4
1 paper
NM_001134.3
p.M285fs
c.853_854fs
1 paper
NM_001134.3
p.S286F
c.857C>T
1 paper
NM_001134.3
p.C289S
c.866G>C
1 paper
NM_001134.3
p.G281_E282Splc
c.844-10T>C
1 paper
NM_001134.3
p.S290S
c.870T>C
1 paper
NM_001134.3
p.S296L
c.887C>T
1 paper
NM_001134.3
p.L305_T306insFs
c.915_916insC
1 paper
NM_001134.3
p.L305L
c.915G>T
1 paper
NM_001134.3
p.R310C
c.928C>T
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