Varaico: Literature-Extracted Genetic Variants

Gene:AKT2
Variant:p.Y351fs

AKT2

617 papers

RefSeq Summary

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The...

Pfam Domains

PHaa 6–108UCSCPH domain
Pkinaseaa 152–409UCSCProtein kinase domain
Pkinase_Caa 430–475UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

AKT serine/threonine kinase 2

HGNC Alias Symbol

PKBβ

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001626.6
p.Y351fs
c.1051_1052fs
Surrounding Variants
3 papers
NM_001626.6
p.Y351C
c.1052A>G
1 paper
NM_001626.6
p.P349L
c.1046C>T
1 paper
NM_001626.6
p.Q353*
c.1057C>T
1 paper
NM_001626.6
p.P349S
c.1045C>T
3 papers
NM_001626.6
p.Q353K
c.1057C>A
1 paper
NM_001626.6
p.Q353R
c.1058A>G
1 paper
NM_001626.6
p.R347H
c.1040G>A
3 papers
NM_001626.6
p.H355Y
c.1063C>T
1 paper
NM_001626.6
p.R347C
c.1039C>T
4 papers
NM_001626.6
p.E356K
c.1066G>A
1 paper
NM_001626.6
p.G346S
c.1036G>A
1 paper
NM_001626.6
p.C345Y
c.1034G>A
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