Varaico: Literature-Extracted Genetic Variants

Gene:AKT2
Variant:p.R245C

AKT2

617 papers

RefSeq Summary

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The...

Pfam Domains

PHaa 6–108UCSCPH domain
Pkinaseaa 152–409UCSCProtein kinase domain
Pkinase_Caa 430–475UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

AKT serine/threonine kinase 2

HGNC Alias Symbol

PKBβ

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_001626.6
p.R245C
c.733C>T
Surrounding Variants
2 papers
NM_001626.6
p.R245H
c.734G>A
1 paper
NM_001626.6
p.V246F
c.736G>T
2 papers
NM_001626.6
p.R243W
c.727C>T
1 paper
NM_001626.6
p.F247S
c.740T>C
1 paper
NM_001626.6
p.E249Q
c.745G>C
3 papers
NM_001626.6
p.R251W
c.751C>T
1 paper
NM_001626.6
p.F238S
c.713T>C
1 paper
NM_001626.6
p.L237L
c.711G>C
1 paper
NM_001626.6
p.A252G
c.755C>G
1 paper
NM_001626.6
p.R253W
c.757C>T
2 papers
NM_001626.6
p.R253Q
c.758G>A
1 paper
NM_001626.6
p.F254L
c.760T>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."