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Varaico: Literature-Extracted Genetic Variants

Include likely false extractions

Gene:ANAPC10

Variant:p.I139M

ANAPC10

27 papers

RefSeq Summary

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid sep...

Pfam Domains

ANAPC10aa 4–183UCSCAnaphase-promoting complex, subunit 10 (APC10)

Gene Aliases

HGNC Name

anaphase promoting complex subunit 10

HGNC Alias Symbols

APC10; DOC1; DKFZP564L0562

Papers

Position

RefSeq ID

Protein change

DNA change

Pfam

gnomAD

Selected Variant

2 papers

chr4:144995514 A>C

NM_001256706.2

p.I139M

c.417T>G

ANAPC10

Exome: 0.1% (AC=859, hom=1)Genome: 0.1% (AC=142, hom=1)64 overlapping SVs

Surrounding Variants

1 paper

chr4:144995504 C>T

NM_001256706.2

p.A143T

c.427G>A

ANAPC10

exact variant not in gnomAD64 overlapping SVs

1 paper

chr4:144995468 G>A

NM_001256706.2

p.Q155*

c.463C>T

ANAPC10

exact variant not in gnomAD64 overlapping SVs

1 paper

chr4:144995463 A>AT

NM_001256706.2

p.I156Fs

c.468delinsATFs

ANAPC10

exact variant not in gnomAD64 overlapping SVs

1 paper

chr4:144995453 T>C

NM_001256706.2

p.T160A

c.478A>G

ANAPC10

Exome: 0.0% (AC=2, hom=0)Genome: n/a64 overlapping SVs

1 paper

chr4:144995383 G>A

NM_001256706.2

p.S183L

c.548C>T

ANAPC10

Exome: 0.0% (AC=138, hom=0)Genome: 0.0% (AC=8, hom=0)64 overlapping SVs

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."